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The Effect of Small Doses of Chemically Pure Secretin on the Volume and Bicarbonate Output of the Pancreatic Juice in Dogs
Säteri, H., L. Thulin and B. Welander. The effect of small doses of chemically pure secretin on the volume and bicarbonate output of the pancreatic juice in dogs. Acta physiol. scand. 1965. 64. 106–108. The volume and bicarbonate output of the pancreatic juice during fasting and during infusion of c...
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Published in: | Acta physiologica Scandinavica 1965-05, Vol.64 (1-2), p.106-108 |
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description | Säteri, H., L. Thulin and B. Welander. The effect of small doses of chemically pure secretin on the volume and bicarbonate output of the pancreatic juice in dogs. Acta physiol. scand. 1965. 64. 106–108. The volume and bicarbonate output of the pancreatic juice during fasting and during infusion of chemically pure secretin at doses without effect on the liver were studied by a non‐surgical method. Eight experiments were made in 2 unanesthetized dogs. The doses ranged from 0.25 to 1.5 clinical units per kg b. w. and hr. At the smaller doses there was only a slight increase of the volume and the bicarbonate output. At the larger doses the maximum volume, 25 ml per 30 min, was about 3 times the initial and the maximum bicarbonate output, 1.4–2.7 meq per 30 min, about 50 times the initial in one dog and about 10 times in the other. |
doi_str_mv | 10.1111/j.1748-1716.1965.tb04158.x |
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Thulin and B. Welander. The effect of small doses of chemically pure secretin on the volume and bicarbonate output of the pancreatic juice in dogs. Acta physiol. scand. 1965. 64. 106–108. The volume and bicarbonate output of the pancreatic juice during fasting and during infusion of chemically pure secretin at doses without effect on the liver were studied by a non‐surgical method. Eight experiments were made in 2 unanesthetized dogs. The doses ranged from 0.25 to 1.5 clinical units per kg b. w. and hr. At the smaller doses there was only a slight increase of the volume and the bicarbonate output. At the larger doses the maximum volume, 25 ml per 30 min, was about 3 times the initial and the maximum bicarbonate output, 1.4–2.7 meq per 30 min, about 50 times the initial in one dog and about 10 times in the other.</description><identifier>ISSN: 0001-6772</identifier><identifier>EISSN: 1365-201X</identifier><identifier>DOI: 10.1111/j.1748-1716.1965.tb04158.x</identifier><identifier>PMID: 14347267</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Bicarbonates ; Dogs ; Old Medline ; Pancreatic Juice ; Pharmacology ; Secretin</subject><ispartof>Acta physiologica Scandinavica, 1965-05, Vol.64 (1-2), p.106-108</ispartof><rights>1965 Scandinavian Physiological Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3546-fc63864413ccfc0a51fa2d8cab9fb5b91b75fe4c20f5cb7820e5cdf4c26491e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1748-1716.1965.tb04158.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1748-1716.1965.tb04158.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1410,27903,27904,46027,46451</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14347267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SÄTERI, H.</creatorcontrib><creatorcontrib>THULIN, L.</creatorcontrib><creatorcontrib>WELANDER, B.</creatorcontrib><title>The Effect of Small Doses of Chemically Pure Secretin on the Volume and Bicarbonate Output of the Pancreatic Juice in Dogs</title><title>Acta physiologica Scandinavica</title><addtitle>Acta Physiol Scand</addtitle><description>Säteri, H., L. Thulin and B. Welander. The effect of small doses of chemically pure secretin on the volume and bicarbonate output of the pancreatic juice in dogs. Acta physiol. scand. 1965. 64. 106–108. The volume and bicarbonate output of the pancreatic juice during fasting and during infusion of chemically pure secretin at doses without effect on the liver were studied by a non‐surgical method. Eight experiments were made in 2 unanesthetized dogs. The doses ranged from 0.25 to 1.5 clinical units per kg b. w. and hr. At the smaller doses there was only a slight increase of the volume and the bicarbonate output. At the larger doses the maximum volume, 25 ml per 30 min, was about 3 times the initial and the maximum bicarbonate output, 1.4–2.7 meq per 30 min, about 50 times the initial in one dog and about 10 times in the other.</description><subject>Animals</subject><subject>Bicarbonates</subject><subject>Dogs</subject><subject>Old Medline</subject><subject>Pancreatic Juice</subject><subject>Pharmacology</subject><subject>Secretin</subject><issn>0001-6772</issn><issn>1365-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1965</creationdate><recordtype>article</recordtype><recordid>eNqVkF1v0zAUhi0EYqXwF5DFBXfJbMcfKTeodGMFTVunjcGd5bjHLCWJi51oLb8eh1ZwjW-sc_S-z5EehN5QktP0Tjc5VbzMqKIypzMp8r4inIoy3z1BE1pIkTFCvz1FE0IIzaRS7AS9iHGTxqJk7Dk6obzgikk1Qb_uHgCfOwe2x97h29Y0DT7zEeI4Lh6grW1a7fFqCIBvwQbo6w77DvepeO-boQVsujX-kHKh8p3pAV8P_Xb4wxtDK9Ollulriz8PtQWc-mf-e3yJnjnTRHh1_Kfoy8fzu8Uyu7y--LSYX2a2EFxmzsqilJzTwlpniRHUGbYuralmrhLVjFZKOOCWESdspUpGQNi1SwvJZxREMUVvD9xt8D8HiL1u62ihaUwHfoi65ISVJCmZoneHoA0-xgBOb0PdmrDXlOjRvN7o0bwezevRvD6a17tUfn28MlQtrP9Vj6pT4P0h8Fg3sP8PtJ6vlnNKZCJkB0Ide9j9JZjwQye-Evrr1YW-urlfkgWX-qb4DTESo6E</recordid><startdate>196505</startdate><enddate>196505</enddate><creator>SÄTERI, H.</creator><creator>THULIN, L.</creator><creator>WELANDER, B.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196505</creationdate><title>The Effect of Small Doses of Chemically Pure Secretin on the Volume and Bicarbonate Output of the Pancreatic Juice in Dogs</title><author>SÄTERI, H. ; THULIN, L. ; WELANDER, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3546-fc63864413ccfc0a51fa2d8cab9fb5b91b75fe4c20f5cb7820e5cdf4c26491e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1965</creationdate><topic>Animals</topic><topic>Bicarbonates</topic><topic>Dogs</topic><topic>Old Medline</topic><topic>Pancreatic Juice</topic><topic>Pharmacology</topic><topic>Secretin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SÄTERI, H.</creatorcontrib><creatorcontrib>THULIN, L.</creatorcontrib><creatorcontrib>WELANDER, B.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta physiologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SÄTERI, H.</au><au>THULIN, L.</au><au>WELANDER, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Small Doses of Chemically Pure Secretin on the Volume and Bicarbonate Output of the Pancreatic Juice in Dogs</atitle><jtitle>Acta physiologica Scandinavica</jtitle><addtitle>Acta Physiol Scand</addtitle><date>1965-05</date><risdate>1965</risdate><volume>64</volume><issue>1-2</issue><spage>106</spage><epage>108</epage><pages>106-108</pages><issn>0001-6772</issn><eissn>1365-201X</eissn><abstract>Säteri, H., L. Thulin and B. Welander. The effect of small doses of chemically pure secretin on the volume and bicarbonate output of the pancreatic juice in dogs. Acta physiol. scand. 1965. 64. 106–108. The volume and bicarbonate output of the pancreatic juice during fasting and during infusion of chemically pure secretin at doses without effect on the liver were studied by a non‐surgical method. Eight experiments were made in 2 unanesthetized dogs. The doses ranged from 0.25 to 1.5 clinical units per kg b. w. and hr. At the smaller doses there was only a slight increase of the volume and the bicarbonate output. At the larger doses the maximum volume, 25 ml per 30 min, was about 3 times the initial and the maximum bicarbonate output, 1.4–2.7 meq per 30 min, about 50 times the initial in one dog and about 10 times in the other.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>14347267</pmid><doi>10.1111/j.1748-1716.1965.tb04158.x</doi><tpages>3</tpages></addata></record> |
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language | eng |
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source | Wiley-Blackwell Journals (Backfile Content) |
subjects | Animals Bicarbonates Dogs Old Medline Pancreatic Juice Pharmacology Secretin |
title | The Effect of Small Doses of Chemically Pure Secretin on the Volume and Bicarbonate Output of the Pancreatic Juice in Dogs |
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