Interaction of Hemoglobin Lepore with Sickle Cell Trait and Microcythemia (Thalassemia) in a Southern Italian Family

An abnormal hemoglobin has been observed in a southern Italian family together with sickle cell hemoglobin and thalassemia (microcythemia). The hematologic study has shown that all the carriers of the abnormal hemoglobin are microcythemic. The hemoglobins of these individuals have been studied by pa...

Full description

Saved in:
Bibliographic Details
Published in:Blood 1965-04, Vol.25 (4), p.457-469
Main Authors: Silvestroni, Ezio, Bianco, Ida, CORRADO, BaGLIONI
Format: Article
Language:English
Subjects:
Anemia
Anemia, Sickle Cell
Biochemical Phenomena
Biochemistry
Blood Protein Electrophoresis
Genetics, Medical
Hemoglobins
Hemoglobins, Abnormal
Humans
Italy
Old Medline
Sickle Cell Trait
Thalassemia
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An abnormal hemoglobin has been observed in a southern Italian family together with sickle cell hemoglobin and thalassemia (microcythemia). The hematologic study has shown that all the carriers of the abnormal hemoglobin are microcythemic. The hemoglobins of these individuals have been studied by paper, starch gel, starch block and agar gel electrophoresis. The abnormal hemoglobin has been isolated and identified by fingerprinting as Hb LeporeBoston. The combination of Hb LeporeBoston with thalassemia and sickle cell trait has been observed in members of this family. The hematologic and biochemical implications of the Hb Lepore/thalassemia disease are discussed.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V25.4.457.457