Hepcidin and disorders of iron metabolism

The hepatic peptide hormone hepcidin is the principal regulator of iron absorption and its tissue distribution. Pathologically increased hepcidin concentrations cause or contribute to iron-restrictive anemias including anemias associated with inflammation, chronic kidney disease and some cancers. He...

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Bibliographic Details
Published in:Annual review of medicine 2011-02, Vol.62 (1), p.347-360
Main Authors: Ganz, Tomas, Nemeth, Elizabeta
Format: Article
Language:English
Subjects:
Aging - metabolism
Anemia
Anemia - metabolism
Animals
Antimicrobial Cationic Peptides - agonists
Antimicrobial Cationic Peptides - antagonists & inhibitors
Antimicrobial Cationic Peptides - metabolism
Cation Transport Proteins - metabolism
Female
Hepatocytes - metabolism
Hepcidins
Hormones
Humans
Inflammation - metabolism
Interleukin-6 - metabolism
Iron
Iron - metabolism
Iron Metabolism Disorders - drug therapy
Iron Metabolism Disorders - metabolism
Iron, Dietary - metabolism
Kidney Diseases - metabolism
Liver
Male
Mice
Neoplasms - metabolism
Pathology
Peptides
Transferrin - metabolism
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Summary:The hepatic peptide hormone hepcidin is the principal regulator of iron absorption and its tissue distribution. Pathologically increased hepcidin concentrations cause or contribute to iron-restrictive anemias including anemias associated with inflammation, chronic kidney disease and some cancers. Hepcidin deficiency results in iron overload in hereditary hemochromatosis and ineffective erythropoiesis. The hepcidin-ferroportin axis is the principal regulator of extracellular iron homeostasis in health and disease, and is a promising target for the diagnosis and treatment of iron disorders and anemias.
ISSN:0066-4219
1545-326X
DOI:10.1146/annurev-med-050109-142444