Angiogenesis after Transplantation of Auto- and Allogenic Cells

Neoangiogenesis after transplantation of auto- and allogenic mononuclears and multipotent stromal cells from the bone marrow was studied on the model of inflammatory angiogenesis. Transplanted auto- and allogenic cells stimulate the formation of new blood vessels in the granulation tissue, this mani...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2010-10, Vol.149 (4), p.457-461
Main Authors: Fatkhudinov, T. Kh, Bol'shakova, G. B, Komissarova, S. V, Arutyunyan, I. V, Rzhaninova, A. A, Goldstein, D. V
Format: Article
Language:English
Subjects:
angiogenesis
Animals
Antigen-antibody reactions
Biomedical and Life Sciences
Biomedicine
Bone Marrow Transplantation
Cell Biology
Collagen
Collagen - biosynthesis
granulation tissue
Granulation Tissue - blood supply
Granulation Tissue - cytology
Inflammation
Internal Medicine
Laboratory Medicine
Male
Monocytes - transplantation
mononuclears
Multipotent Stem Cells - transplantation
multipotent stromal cells
Neovascularization
Neovascularization, Pathologic
Neovascularization, Physiologic - physiology
Pathology
Rats
Rats, Wistar
Stromal Cells - transplantation
Transplantation, Autologous
Transplantation, Homologous
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Summary:Neoangiogenesis after transplantation of auto- and allogenic mononuclears and multipotent stromal cells from the bone marrow was studied on the model of inflammatory angiogenesis. Transplanted auto- and allogenic cells stimulate the formation of new blood vessels in the granulation tissue, this manifesting in an increase in the quantity and volume density of blood vessels. The most pronounced angiogenesis was observed after transplantation of allogenic mononuclears and multipotent stromal cells. It was associated with intense inflammatory infiltration, with less numerous and mature collagen fibers in the granulation tissue. Injection of allogenic cells led to stimulation and chronization of inflammation, infiltration with inflammatory and poorly differentiated cells, and more pronounced and lasting angiogenesis. However, neither auto-, nor allogenic transplanted labeled cells were detected in the walls of new blood vessels. Hence, it seems that bone marrow mononuclears and multipotent stromal cells stimulated angiogenesis mainly at the expense of production of angiogenic factors, and after transplantation of allogenic cells also by stimulating the inflammation.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-010-0970-8