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Angiogenesis after Transplantation of Auto- and Allogenic Cells
Neoangiogenesis after transplantation of auto- and allogenic mononuclears and multipotent stromal cells from the bone marrow was studied on the model of inflammatory angiogenesis. Transplanted auto- and allogenic cells stimulate the formation of new blood vessels in the granulation tissue, this mani...
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| Published in: | Bulletin of experimental biology and medicine 2010-10, Vol.149 (4), p.457-461 |
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| container_end_page | 461 |
| container_issue | 4 |
| container_start_page | 457 |
| container_title | Bulletin of experimental biology and medicine |
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| creator | Fatkhudinov, T. Kh Bol'shakova, G. B Komissarova, S. V Arutyunyan, I. V Rzhaninova, A. A Goldstein, D. V |
| description | Neoangiogenesis after transplantation of auto- and allogenic mononuclears and multipotent stromal cells from the bone marrow was studied on the model of inflammatory angiogenesis. Transplanted auto- and allogenic cells stimulate the formation of new blood vessels in the granulation tissue, this manifesting in an increase in the quantity and volume density of blood vessels. The most pronounced angiogenesis was observed after transplantation of allogenic mononuclears and multipotent stromal cells. It was associated with intense inflammatory infiltration, with less numerous and mature collagen fibers in the granulation tissue. Injection of allogenic cells led to stimulation and chronization of inflammation, infiltration with inflammatory and poorly differentiated cells, and more pronounced and lasting angiogenesis. However, neither auto-, nor allogenic transplanted labeled cells were detected in the walls of new blood vessels. Hence, it seems that bone marrow mononuclears and multipotent stromal cells stimulated angiogenesis mainly at the expense of production of angiogenic factors, and after transplantation of allogenic cells also by stimulating the inflammation. |
| doi_str_mv | 10.1007/s10517-010-0970-8 |
| format | article |
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Kh ; Bol'shakova, G. B ; Komissarova, S. V ; Arutyunyan, I. V ; Rzhaninova, A. A ; Goldstein, D. V</creator><creatorcontrib>Fatkhudinov, T. Kh ; Bol'shakova, G. B ; Komissarova, S. V ; Arutyunyan, I. V ; Rzhaninova, A. A ; Goldstein, D. V</creatorcontrib><description>Neoangiogenesis after transplantation of auto- and allogenic mononuclears and multipotent stromal cells from the bone marrow was studied on the model of inflammatory angiogenesis. Transplanted auto- and allogenic cells stimulate the formation of new blood vessels in the granulation tissue, this manifesting in an increase in the quantity and volume density of blood vessels. The most pronounced angiogenesis was observed after transplantation of allogenic mononuclears and multipotent stromal cells. It was associated with intense inflammatory infiltration, with less numerous and mature collagen fibers in the granulation tissue. Injection of allogenic cells led to stimulation and chronization of inflammation, infiltration with inflammatory and poorly differentiated cells, and more pronounced and lasting angiogenesis. However, neither auto-, nor allogenic transplanted labeled cells were detected in the walls of new blood vessels. Hence, it seems that bone marrow mononuclears and multipotent stromal cells stimulated angiogenesis mainly at the expense of production of angiogenic factors, and after transplantation of allogenic cells also by stimulating the inflammation.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-010-0970-8</identifier><identifier>PMID: 21234443</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>angiogenesis ; Animals ; Antigen-antibody reactions ; Biomedical and Life Sciences ; Biomedicine ; Bone Marrow Transplantation ; Cell Biology ; Collagen ; Collagen - biosynthesis ; granulation tissue ; Granulation Tissue - blood supply ; Granulation Tissue - cytology ; Inflammation ; Internal Medicine ; Laboratory Medicine ; Male ; Monocytes - transplantation ; mononuclears ; Multipotent Stem Cells - transplantation ; multipotent stromal cells ; Neovascularization ; Neovascularization, Pathologic ; Neovascularization, Physiologic - physiology ; Pathology ; Rats ; Rats, Wistar ; Stromal Cells - transplantation ; Transplantation, Autologous ; Transplantation, Homologous</subject><ispartof>Bulletin of experimental biology and medicine, 2010-10, Vol.149 (4), p.457-461</ispartof><rights>Springer Science+Business Media, Inc. 2010</rights><rights>COPYRIGHT 2010 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-cb7323d6d42cf119d8aaecc6d1830b2bda62b38322ab79d43818bacd2c4af0d23</citedby><cites>FETCH-LOGICAL-c492t-cb7323d6d42cf119d8aaecc6d1830b2bda62b38322ab79d43818bacd2c4af0d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21234443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fatkhudinov, T. Kh</creatorcontrib><creatorcontrib>Bol'shakova, G. B</creatorcontrib><creatorcontrib>Komissarova, S. V</creatorcontrib><creatorcontrib>Arutyunyan, I. V</creatorcontrib><creatorcontrib>Rzhaninova, A. A</creatorcontrib><creatorcontrib>Goldstein, D. V</creatorcontrib><title>Angiogenesis after Transplantation of Auto- and Allogenic Cells</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Neoangiogenesis after transplantation of auto- and allogenic mononuclears and multipotent stromal cells from the bone marrow was studied on the model of inflammatory angiogenesis. Transplanted auto- and allogenic cells stimulate the formation of new blood vessels in the granulation tissue, this manifesting in an increase in the quantity and volume density of blood vessels. The most pronounced angiogenesis was observed after transplantation of allogenic mononuclears and multipotent stromal cells. 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Kh</au><au>Bol'shakova, G. B</au><au>Komissarova, S. V</au><au>Arutyunyan, I. V</au><au>Rzhaninova, A. A</au><au>Goldstein, D. V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiogenesis after Transplantation of Auto- and Allogenic Cells</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>149</volume><issue>4</issue><spage>457</spage><epage>461</epage><pages>457-461</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><coden>BEXBAN</coden><abstract>Neoangiogenesis after transplantation of auto- and allogenic mononuclears and multipotent stromal cells from the bone marrow was studied on the model of inflammatory angiogenesis. Transplanted auto- and allogenic cells stimulate the formation of new blood vessels in the granulation tissue, this manifesting in an increase in the quantity and volume density of blood vessels. The most pronounced angiogenesis was observed after transplantation of allogenic mononuclears and multipotent stromal cells. It was associated with intense inflammatory infiltration, with less numerous and mature collagen fibers in the granulation tissue. Injection of allogenic cells led to stimulation and chronization of inflammation, infiltration with inflammatory and poorly differentiated cells, and more pronounced and lasting angiogenesis. However, neither auto-, nor allogenic transplanted labeled cells were detected in the walls of new blood vessels. 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| subjects | angiogenesis Animals Antigen-antibody reactions Biomedical and Life Sciences Biomedicine Bone Marrow Transplantation Cell Biology Collagen Collagen - biosynthesis granulation tissue Granulation Tissue - blood supply Granulation Tissue - cytology Inflammation Internal Medicine Laboratory Medicine Male Monocytes - transplantation mononuclears Multipotent Stem Cells - transplantation multipotent stromal cells Neovascularization Neovascularization, Pathologic Neovascularization, Physiologic - physiology Pathology Rats Rats, Wistar Stromal Cells - transplantation Transplantation, Autologous Transplantation, Homologous |
| title | Angiogenesis after Transplantation of Auto- and Allogenic Cells |
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