Tin Mediated Allylation Reactions of Enol Ethers in Water

Under tin-mediated Barbier-type reaction conditions, hydration of enol ethers takes place to form aldehydes that undergo allylation reactions. By using this process, various homoallylic alcohols and 2-halohomoallylic alcohols are produced in good to excellent yields.

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Bibliographic Details
Published in:Organic letters 2011-01, Vol.13 (2), p.332-335
Main Authors: Lin, Mei-Huey, Hung, Shiang-Fu, Lin, Long-Zhi, Tsai, Wen-Shing, Chuang, Tsung-Hsun
Format: Article
Language:English
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Summary:Under tin-mediated Barbier-type reaction conditions, hydration of enol ethers takes place to form aldehydes that undergo allylation reactions. By using this process, various homoallylic alcohols and 2-halohomoallylic alcohols are produced in good to excellent yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol102825t