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4D traction force microscopy reveals asymmetric cortical forces in migrating Dictyostelium cells

We present a 4D (x; y; z; t) force map of Dictyostelium cells crawling on a soft gel substrate. Vertical forces are of the same order as the tangential ones. The cells pull the substratum upward along the cell, medium, or substratum contact line and push it downward under the cell except for the pse...

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Bibliographic Details
Published in:Physical review letters 2010-12, Vol.105 (24), p.248103-248103, Article 248103
Main Authors: Delanoë-Ayari, H, Rieu, J P, Sano, M
Format: Article
Language:English
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Summary:We present a 4D (x; y; z; t) force map of Dictyostelium cells crawling on a soft gel substrate. Vertical forces are of the same order as the tangential ones. The cells pull the substratum upward along the cell, medium, or substratum contact line and push it downward under the cell except for the pseudopods. We demonstrate quantitatively that the variations in the asymmetry in cortical forces correlates with the variations of the direction and speed of cell displacement.
ISSN:0031-9007
1079-7114
DOI:10.1103/PhysRevLett.105.248103