Efficacy and Safety of Dofetilide in the Treatment of Frequent Ventricular Tachyarrhythmias After Amiodarone Intolerance or Failure

All but 1 patient was male, most patients had a history of coronary artery disease, their average left ventricular ejection fraction was 30%, and all received the ICD for secondary prophylaxis. Post p Value VT/VF episodes 21(7,70.75) 9(3.75,39.5) 0.064 11(2.75,46.5) 3(0.75,8.5) 0.007 Total shocks 5(...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American College of Cardiology 2011-01, Vol.57 (3), p.380-381
Main Authors: Pinter, Arnold, MD, Akhtari, Shadi, MD, O'Connell, Timothy, MD, O'Donnell, Suzan, MSc, Mangat, Iqwal, MD, Korley, Victoria, MD, Ahmad, Kamran, MD, Posan, Emoke, MD, PhD, Newman, David, MD, Dorian, Paul, MD, MSc
Format: Article
Language:English
Subjects:
Amiodarone - adverse effects
Amiodarone - therapeutic use
Biological and medical sciences
Cardiac arrhythmia
Cardiology
Cardiology. Vascular system
Cardiovascular
Cohort Studies
Female
Heart attacks
Humans
Internal Medicine
Lightning
Male
Medical sciences
Mortality
Phenethylamines - adverse effects
Phenethylamines - therapeutic use
Sulfonamides - adverse effects
Sulfonamides - therapeutic use
Tachycardia, Ventricular - drug therapy
Tachycardia, Ventricular - physiopathology
Time Factors
Treatment Failure
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:All but 1 patient was male, most patients had a history of coronary artery disease, their average left ventricular ejection fraction was 30%, and all received the ICD for secondary prophylaxis. Post p Value VT/VF episodes 21(7,70.75) 9(3.75,39.5) 0.064 11(2.75,46.5) 3(0.75,8.5) 0.007 Total shocks 5(1,15) 1.5(0,6.5) 0.074 1.5(0,7.75) 0.5(0,5) 0.197 Appropriate shocks 2(0,9.25) 0.5(0,5) 0.139 1(0,7.75) 0(0,3.5) 0.091 Inappropriate shocks 0(0,0.25) 0(0,0) 0.273 0(0,0) 0(0,0) 1.000 Appropriate ATP 8.5(1.75,70.25) 5(2,31.25) 0.206 6.5(0,21.75) 1.5(0,4.75) 0.092 Inappropriate ATP 0(0,0.25) 0(0,0) 0.686 0(0,0) 0(0,0) 0.655 Inappropriate shocks + ATP 0(0,0.75) 0(0,0) 0.686 0(0,0) 0(0,0) 0.715 Nonsustained episodes 17(0.75,55) 1.5(0,42.75) 0.249 1(0,14.5) 0(0,2.25) 0.049 Electrical storm episodes 1.5(1,6) 0(0,1) 0.085 1(0,3) 0(0,1) 0.005 Hospitalization (all-cause) 2(1,2) 0(0,1) 0.003 -- -- -- Table 1 Medium-Term (15 Months) and Short-Term (3 Months) Efficacy of Dofetilide Values are given as median (25th, 75th percentiles), except as indicated.ATP = anti-tachycardia pacing; VF = ventricular fibrillation; VT = ventricular tachycardia.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2010.07.047