Cerebral arterial smooth muscle contraction by thromboxane A2

The contractile effects of thromboxane A2 (TxA2), a labile arachidonic acid metabolite, were studied in arterial smooth muscle strips. TxA2 was generated upon the addition of 255 nM prostaglandin cyclic endoperoxide H2 to human platelet particles in the muscle bath. Using the isometric contaction pr...

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Bibliographic Details
Published in:Stroke (1970) 1977-07, Vol.8 (4), p.480-483
Main Authors: Ellis, E F, Nies, A S, Oates, J A
Format: Article
Language:English
Subjects:
Animals
Blood Platelets - metabolism
Carotid Arteries - drug effects
Cattle
Cerebral Arteries - drug effects
Coronary Vessels - drug effects
Humans
Hydroxy Acids - biosynthesis
Hydroxy Acids - pharmacology
In Vitro Techniques
Ischemic Attack, Transient - etiology
Muscle Contraction - drug effects
Muscle, Smooth - drug effects
Peroxides - metabolism
Prostaglandins - metabolism
Pyrans - biosynthesis
Pyrans - pharmacology
Renal Artery - drug effects
Swine
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Summary:The contractile effects of thromboxane A2 (TxA2), a labile arachidonic acid metabolite, were studied in arterial smooth muscle strips. TxA2 was generated upon the addition of 255 nM prostaglandin cyclic endoperoxide H2 to human platelet particles in the muscle bath. Using the isometric contaction produced by 40 mM K+ in isotonic saline as the reference contraction, bovine middle cerebral artery strips contracted to 153 +/- 14% of the reference response while bovine coronary and porcine coronary, renal and common carotid strips contracted to 47 +/- 3, 26 +/- 5, 43 +/- 2 and 2 +/- 1% of reference, respectively. The cerebral artery response to the TxA2 generating system was as great as the maximum response to prostaglandin F2alpha and two times the maximum response to 5-hydroxytryptamine. Because TxA2 is formed by brain tissue and released from aggregating platelets, it may be important in the pathogenesis of spasm associated with injured brain tissue or pathologic changes leading to platelet aggregation.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.str.8.4.480