Thyroxinlike Activity of Several Thyroxin Analogs

Five analogs of thyroxin were tested for thyroxinlike activity on the basis of the Rana catesbiana tail fin assay procedure. Two of them, 3,5-diiodo-4-(3′,5′-diiodo-4-hydroxyphenoxy)-phenylpropionic acid and 3,5-diiodo-4-(3′,5′-diiodo-4-hydroxyphenoxy)-phenylbutyric acid, were by this test many time...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1965-03, Vol.54 (3), p.493-494
Main Authors: Kulik, Margaret H., Bester, John F.
Format: Article
Language:English
Subjects:
Animals
Antithyroid Agents
Anura
Metamorphosis, Biological
Old Medline
Pharmacology
Thyroid Hormones
Thyroxine
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Summary:Five analogs of thyroxin were tested for thyroxinlike activity on the basis of the Rana catesbiana tail fin assay procedure. Two of them, 3,5-diiodo-4-(3′,5′-diiodo-4-hydroxyphenoxy)-phenylpropionic acid and 3,5-diiodo-4-(3′,5′-diiodo-4-hydroxyphenoxy)-phenylbutyric acid, were by this test many times more potent than L-thyroxin; one of them, 3,5-diiodo-4-(3′,5′-dimethyl-4-hydroxyphenyl)-phenylalanine, was slightly more potent than L-thyroxin.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600540346