Particles Resembling Papova Viruses in Human Cerebral Demyelinating Disease

Degenerated brain tissue obtained from a deceased patient who had progressive multifocal leukoencephalopathy had been fixed in formalin prior to processing for electron microscopy. In ultrathin sections virus-like particles resembling papova virions were frequently observed in glial nuclei. Correlat...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1965-06, Vol.148 (3676), p.1477-1479
Main Authors: Gabriele M. Zu Rhein, Chou, Shi-Ming
Format: Article
Language:English
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Summary:Degenerated brain tissue obtained from a deceased patient who had progressive multifocal leukoencephalopathy had been fixed in formalin prior to processing for electron microscopy. In ultrathin sections virus-like particles resembling papova virions were frequently observed in glial nuclei. Correlation with light-microscopy findings suggests that demyelination resulted from the cytocidal effect of the virus on oligodendroglia.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.148.3676.1477