Amantadine-resistance as a Genetic Marker for Influenza Viruses

Microbiological Research Establishment, Porton, Nr Salisbury, Wiltshire, U.K. The infection of eggs, cell cultures or mice with a mixture of amantadine-resistant and amantadine-sensitive strains of influenza virus resulted in the transfer of amantadine-resistance or sensitivity between strains. The...

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Bibliographic Details
Published in:Journal of general virology 1977-08, Vol.36 (2), p.249-255
Main Author: Appleyard, G
Format: Article
Language:English
Subjects:
Amantadine - pharmacology
Animals
Chick Embryo
Drug Resistance, Microbial
Genes
Orthomyxoviridae - drug effects
Orthomyxoviridae - growth & development
Recombination, Genetic
Virus Replication - drug effects
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Summary:Microbiological Research Establishment, Porton, Nr Salisbury, Wiltshire, U.K. The infection of eggs, cell cultures or mice with a mixture of amantadine-resistant and amantadine-sensitive strains of influenza virus resulted in the transfer of amantadine-resistance or sensitivity between strains. The response of a recombinant virus to amantadine was not related to either of its surface antigens. Resistance to amantadine was transferred as an all-or-none character. It is concluded that amantadine-resistance is a useful genetic marker for influenza viruses. Received 7 February 1977; accepted 2 March 1977.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-36-2-249