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Amantadine-resistance as a Genetic Marker for Influenza Viruses
Microbiological Research Establishment, Porton, Nr Salisbury, Wiltshire, U.K. The infection of eggs, cell cultures or mice with a mixture of amantadine-resistant and amantadine-sensitive strains of influenza virus resulted in the transfer of amantadine-resistance or sensitivity between strains. The...
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Published in: | Journal of general virology 1977-08, Vol.36 (2), p.249-255 |
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container_end_page | 255 |
container_issue | 2 |
container_start_page | 249 |
container_title | Journal of general virology |
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creator | Appleyard, G |
description | Microbiological Research Establishment, Porton, Nr Salisbury, Wiltshire, U.K.
The infection of eggs, cell cultures or mice with a mixture of amantadine-resistant and amantadine-sensitive strains of influenza virus resulted in the transfer of amantadine-resistance or sensitivity between strains. The response of a recombinant virus to amantadine was not related to either of its surface antigens. Resistance to amantadine was transferred as an all-or-none character. It is concluded that amantadine-resistance is a useful genetic marker for influenza viruses.
Received 7 February 1977;
accepted 2 March 1977. |
doi_str_mv | 10.1099/0022-1317-36-2-249 |
format | article |
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The infection of eggs, cell cultures or mice with a mixture of amantadine-resistant and amantadine-sensitive strains of influenza virus resulted in the transfer of amantadine-resistance or sensitivity between strains. The response of a recombinant virus to amantadine was not related to either of its surface antigens. Resistance to amantadine was transferred as an all-or-none character. It is concluded that amantadine-resistance is a useful genetic marker for influenza viruses.
Received 7 February 1977;
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The infection of eggs, cell cultures or mice with a mixture of amantadine-resistant and amantadine-sensitive strains of influenza virus resulted in the transfer of amantadine-resistance or sensitivity between strains. The response of a recombinant virus to amantadine was not related to either of its surface antigens. Resistance to amantadine was transferred as an all-or-none character. It is concluded that amantadine-resistance is a useful genetic marker for influenza viruses.
Received 7 February 1977;
accepted 2 March 1977.</description><subject>Amantadine - pharmacology</subject><subject>Animals</subject><subject>Chick Embryo</subject><subject>Drug Resistance, Microbial</subject><subject>Genes</subject><subject>Orthomyxoviridae - drug effects</subject><subject>Orthomyxoviridae - growth & development</subject><subject>Recombination, Genetic</subject><subject>Virus Replication - drug effects</subject><issn>0022-1317</issn><issn>1465-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><recordid>eNo9kDtPwzAUhS3EqxT-AGLIBJPBj9hOJlRVUCoVsQCr5SbXrSFxip2A4NeTKlWnO3znnCt9CF1ScktJnt8RwhimnCrMJWaYpfkBGtFUCsx6fIhG-8ApOovxgxCapkKdoGMhKZV8hO4ntfGtKZ0HHCC62BpfQGJiYpIZeGhdkTyb8AkhsU1I5t5WHfg_k7y70EWI5-jImirCxe6O0dvjw-v0CS9eZvPpZIGLlLAWF4IryhgHIvLClIyXQkCZp4SXuVUZt5xmRbYURGaUZDwDakthc7AyZSpXlo_R9bC7Cc1XB7HVtYsFVJXx0HRRZykRSjLVB9kQLEITYwCrN8HVJvxqSvRWmt460VsnmkvNdC-tL13t1rtlDeW-Mljq8c2A1261_nEB9Ap87foPS9fobxf2Q__2GnOi</recordid><startdate>197708</startdate><enddate>197708</enddate><creator>Appleyard, G</creator><general>Soc General Microbiol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197708</creationdate><title>Amantadine-resistance as a Genetic Marker for Influenza Viruses</title><author>Appleyard, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-c5371223e059cad23d55ed9403d9f783f318c8b506810838e1fd5f9ef642797f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Amantadine - pharmacology</topic><topic>Animals</topic><topic>Chick Embryo</topic><topic>Drug Resistance, Microbial</topic><topic>Genes</topic><topic>Orthomyxoviridae - drug effects</topic><topic>Orthomyxoviridae - growth & development</topic><topic>Recombination, Genetic</topic><topic>Virus Replication - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Appleyard, G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of general virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Appleyard, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amantadine-resistance as a Genetic Marker for Influenza Viruses</atitle><jtitle>Journal of general virology</jtitle><addtitle>J Gen Virol</addtitle><date>1977-08</date><risdate>1977</risdate><volume>36</volume><issue>2</issue><spage>249</spage><epage>255</epage><pages>249-255</pages><issn>0022-1317</issn><eissn>1465-2099</eissn><abstract>Microbiological Research Establishment, Porton, Nr Salisbury, Wiltshire, U.K.
The infection of eggs, cell cultures or mice with a mixture of amantadine-resistant and amantadine-sensitive strains of influenza virus resulted in the transfer of amantadine-resistance or sensitivity between strains. The response of a recombinant virus to amantadine was not related to either of its surface antigens. Resistance to amantadine was transferred as an all-or-none character. It is concluded that amantadine-resistance is a useful genetic marker for influenza viruses.
Received 7 February 1977;
accepted 2 March 1977.</abstract><cop>England</cop><pub>Soc General Microbiol</pub><pmid>561163</pmid><doi>10.1099/0022-1317-36-2-249</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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issn | 0022-1317 1465-2099 |
language | eng |
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source | Freely Accessible Journals |
subjects | Amantadine - pharmacology Animals Chick Embryo Drug Resistance, Microbial Genes Orthomyxoviridae - drug effects Orthomyxoviridae - growth & development Recombination, Genetic Virus Replication - drug effects |
title | Amantadine-resistance as a Genetic Marker for Influenza Viruses |
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