Effect of di-n-propylacetate on the 'binding of GABA to synaptosome-enriched fraction of rat cerebral cortex

The effect of di-n-propylacetate (DPA) on the 'binding' of gamma-aminobutyric acid (GABA) to a synaptosome-enriched fraction of rat cerebral cortex has been examined using differential centrifugation and double-isotope liquid scintillation spectrometry. DPA at 10(-4) M caused a slight decr...

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Bibliographic Details
Published in:Psychopharmacology 1977-01, Vol.53 (3), p.255-257
Main Authors: Kulig, B M, Gonzalez-Portal, C, Somoza, E, Defeudis, F V
Format: Article
Language:English
Subjects:
Aminobutyrates - metabolism
Animals
Cerebral Cortex - drug effects
Cerebral Cortex - metabolism
Cerebral Cortex - ultrastructure
gamma-Aminobutyric Acid - metabolism
In Vitro Techniques
Male
Nerve Tissue Proteins - metabolism
Rats
Synaptosomes - drug effects
Synaptosomes - metabolism
Valerates - pharmacology
Valproic Acid - pharmacology
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Summary:The effect of di-n-propylacetate (DPA) on the 'binding' of gamma-aminobutyric acid (GABA) to a synaptosome-enriched fraction of rat cerebral cortex has been examined using differential centrifugation and double-isotope liquid scintillation spectrometry. DPA at 10(-4) M caused a slight decrease in GABA binding. This effect could explain in part the in vivo anticonvulsant and behavioral effects of this drug when administered to animals in high systemic doses.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00492360