The quantitative relationship of carcinoembryonic antigen to tumor cells of different organs

Carcinoembryonic antigen (CEA) was measured in extracts of cell suspensions from tumors of the colon, stomach, breast, lung and kidney. Cell suspensions were also obtained from normal tissue surrounding the primary tumors. The number of neoplastic cells in each cell suspension was determined by cyto...

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Bibliographic Details
Published in:Cancer 1977-08, Vol.40 (2), p.808-812
Main Authors: Macsween, J. M., Anderson, G. H.
Format: Article
Language:English
Subjects:
Breast - immunology
Breast Neoplasms - immunology
Carcinoembryonic Antigen - analysis
Colon - immunology
Colonic Neoplasms - immunology
Female
Humans
Kidney - immunology
Kidney Neoplasms - immunology
Lung - immunology
Lung Neoplasms - immunology
Male
Neoplasms - immunology
Organ Specificity
Stomach - immunology
Stomach Neoplasms - immunology
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Summary:Carcinoembryonic antigen (CEA) was measured in extracts of cell suspensions from tumors of the colon, stomach, breast, lung and kidney. Cell suspensions were also obtained from normal tissue surrounding the primary tumors. The number of neoplastic cells in each cell suspension was determined by cytologic criteria. Highest CEA concentrations were found in cells obtained from carcinoma of the bowel. There also appeared to be a greater difference between the concentrations of CEA in colonic tumors and either surrounding normal tissue or serum, than in tumors of other organs. There was no apparent correlation of the concentration of CEA in tumor cells and the presence or absence of metastases. The presence of CEA in normal cells from tissue adjacent to tumors was suggestive of increased synthesis of CEA by these cells in some cases. Cancer 40:808–812, 1977.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(197708)40:2<808::AID-CNCR2820400232>3.0.CO;2-I