Cell Proliferation and Histologic Classification of Bronchogenic Carcinoma

The rate of cell proliferation of 99 bronchogenic carcinomas (94 primary tumors and 5 metastases) was evaluated from the labeling index after in vitro incorporation of [3H]thymidine; the rate was then correlated with the histologic tumor type according to the classification of the World Health Organ...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1977-10, Vol.59 (4), p.1113-1118
Main Authors: Hainau, Bo, Dombernowsky, Per, Hansen, Heine H., Borgeskov, Sven
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Adult
Aged
Carcinoma, Bronchogenic - metabolism
Carcinoma, Bronchogenic - pathology
Carcinoma, Small Cell - metabolism
Carcinoma, Small Cell - pathology
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Cell Differentiation
Cell Division
Female
Humans
Kinetics
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Male
Middle Aged
Neoplasm Metastasis - pathology
Thymidine - metabolism
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Summary:The rate of cell proliferation of 99 bronchogenic carcinomas (94 primary tumors and 5 metastases) was evaluated from the labeling index after in vitro incorporation of [3H]thymidine; the rate was then correlated with the histologic tumor type according to the classification of the World Health Organization (WHO). Cell proliferation was significantly slower in adenocarcinoma (WHO type III) than in squamous cell carcinoma (WHO type I), small cell anaplastic carcinoma (WHO type II), and large cell carcinoma (WHO type IV). Cells proliferated at a significantly higher rate in large cell carcinoma than in the squamous cell type, whereas no significant difference was observed between the other cell types. Dedifferentiated forms of squamous cell carcinomas had a higher rate of cell proliferation than did differentiated forms of the same cell type. Metastases of small cell anaplastic carcinoma did not differ in cell proliferation from primary tumors of the same cell type.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/59.4.1113