Treatment with metronidazole of 48 patients with serious anaerobic infections

Forty-eight patients in whom 50 serious anaerobic infections were diagnosed, were treated with metronidazole either orally (33) or rectally (15). Complete recovery occurred in 38 infections, while in 9 there was a satisfactory response, and 3 were considered as treatment failures. Thirteen of the 15...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1977-07, Vol.3 (4), p.347-353
Main Authors: Giamarellon, H., Kanellakopoulou, K., Pragastis, D., Tagaris, N., Daikos, G. K.
Format: Article
Language:English
Subjects:
Administration, Oral
Adolescent
Adult
Aged
Anaerobiosis
Bacterial Infections - drug therapy
Bacterial Infections - microbiology
Female
Humans
Male
Metronidazole - administration & dosage
Metronidazole - blood
Metronidazole - therapeutic use
Middle Aged
Rectum
Suppositories
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Summary:Forty-eight patients in whom 50 serious anaerobic infections were diagnosed, were treated with metronidazole either orally (33) or rectally (15). Complete recovery occurred in 38 infections, while in 9 there was a satisfactory response, and 3 were considered as treatment failures. Thirteen of the 15 patients treated with suppositories had a complete recovery, while the other patients had a satisfactory response. Serum levels for metronidazole were obtained in 19 patients as well as in 12 volunteers. Similar peak levels, ranging between 10 to 30 mg/l were found after either the oral or rectal route. Sustained high levels were obtained when using the rectal route.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/3.4.347