Puromycin Effect on Successive Phases of Memory Storage

Mice injected bitemporally with puromycin 5 hours before training learned to escape or to avoid shock by choosing the correct limb of a Y-maze. When retested 15 minutes after training they had normal retention. In the ensuing 2$\frac{3}{4}$ hours the animals injected with puromycin, unlike the contr...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1966-02, Vol.151 (3710), p.594-595
Main Authors: Barondes, Samuel H., Cohen, Harry D.
Format: Article
Language:English
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Summary:Mice injected bitemporally with puromycin 5 hours before training learned to escape or to avoid shock by choosing the correct limb of a Y-maze. When retested 15 minutes after training they had normal retention. In the ensuing 2$\frac{3}{4}$ hours the animals injected with puromycin, unlike the controls, showed a progressive decrease of savings to less than 7 percent.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.151.3710.594