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Autoimmune Encephalomyelitis and Ocular Lesions in Monkeys Sensitized during the Neonatal Period

The neonatal rhesus monkey is susceptible to the induction of autoimmune encephalomyelitis. The disease has been produced regularly by injection of neonatal animals with guinea pig spinal cord antigen in complete Freund's adjuvant. The onset of the disease, as compared with onset in adults, is...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1966-01, Vol.151 (3709), p.473-475
Main Authors: Stone, S. H., Lerner, E. M., Myers, R. E., Niemann, W. H.
Format: Article
Language:English
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Summary:The neonatal rhesus monkey is susceptible to the induction of autoimmune encephalomyelitis. The disease has been produced regularly by injection of neonatal animals with guinea pig spinal cord antigen in complete Freund's adjuvant. The onset of the disease, as compared with onset in adults, is delayed and is most often heralded by intrinsic eye lesions, notably widespread retinal hemorrhages.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.151.3709.473