Plateletpheresis in the Management of Thrombocytosis

Acute thrombotic and hemorrhagic manifestations of thrombocytosis associated with myeloproliferative disorders may be life threatening. Conventional therapy with radioisotopes and/or cytotoxic drugs may require weeks for effective control of platelet counts. In five patients, plateletpheresis by dis...

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Bibliographic Details
Published in:Blood 1977-11, Vol.50 (5), p.927-933
Main Authors: Taft, Edwin G., Babcock, Robert B., Scharfman, William B., Tartaglia, Anthony P.
Format: Article
Language:English
Subjects:
Adult
Aged
Female
Humans
Male
Middle Aged
Plasmapheresis
Thrombocytosis - therapy
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Summary:Acute thrombotic and hemorrhagic manifestations of thrombocytosis associated with myeloproliferative disorders may be life threatening. Conventional therapy with radioisotopes and/or cytotoxic drugs may require weeks for effective control of platelet counts. In five patients, plateletpheresis by discontinuous-flow (Haemonetics) or continuous-flow (Aminco Celltrifuge) centrifugation was used as a means of reducing platelet counts acutely. With each procedure, approximately 2-9 × 1012 platelets were removed, resulting in decrements in platelet counts and relief of symptoms. Plateletpheresis is a useful and safe acute means of controlling platelet counts in myeloproliferative disorders.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V50.5.927.927