Reactivity of rheumatoid factor with autologous IgG antibodies

Patients with rheumatoid arthritis and normal subjects were immunized with sheep cell stromata. The isolated rheumatoid factor (RF) from 6 patients with rheumatoid arthritis showed reactivity with autologous IgG anti‐sheep cell antibody coated onto sheep erythrocytes, whereas the whole serum failed...

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Bibliographic Details
Published in:Arthritis and rheumatism 1969-04, Vol.12 (2), p.74-81
Main Authors: Bandilla, K K, McDuffie, F C
Format: Article
Language:English
Subjects:
Animals
Antigen-Antibody Reactions
Arthritis, Rheumatoid - immunology
Autoantibodies
Chromatography
Erythrocytes
Hemagglutination Inhibition Tests
Hemagglutination Tests
Humans
Hydrogen-Ion Concentration
Immunoglobulin G
Immunoglobulin M
Rheumatoid Factor
Sheep
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Summary:Patients with rheumatoid arthritis and normal subjects were immunized with sheep cell stromata. The isolated rheumatoid factor (RF) from 6 patients with rheumatoid arthritis showed reactivity with autologous IgG anti‐sheep cell antibody coated onto sheep erythrocytes, whereas the whole serum failed to agglutinate antibody coated cells. The Gm type of the antibody, denaturation, and antigen‐antibody complex formation could be excluded as factors leading to autoreactivity. Inhibition studies suggested that RF has a greater affinity for autologous native IgG than for isologous IgG.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780120203