Preferential Synthesis of Ferritin and Albumin by Different Populations of Liver Polysomes

Free polysomes and a mixture of free and membrane-attached polysomes were isolated separately from rat liver, and each was added to a cell-free, protein-synthesizing system. The free polysomes showed a greater capacity than the mixed polysome population for incorporation of $^{14}$C-leucine into fer...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1969-05, Vol.164 (3879), p.584-585
Main Authors: Hicks, Sonja J., Drysdale, J. W., Munro, H. N.
Format: Article
Language:English
Subjects:
Albumins
Amino acids
Amino Acids - metabolism
Animals
Biosynthesis
Carbon Isotopes
Cell free system
Ferritins
Ferritins - biosynthesis
Leucine - metabolism
Liver
Liver - cytology
Liver - metabolism
Liver cells
Peptide Biosynthesis
Polyribosomes
Radioactive decay
Rats
Ribosomes - metabolism
Serum Albumin - biosynthesis
Serum albumins
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Summary:Free polysomes and a mixture of free and membrane-attached polysomes were isolated separately from rat liver, and each was added to a cell-free, protein-synthesizing system. The free polysomes showed a greater capacity than the mixed polysome population for incorporation of $^{14}$C-leucine into ferritin, whereas the reverse was true for $^{14}$C-leucine incorporation into albumin.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.164.3879.584