Pathology of the conduction system in cardiac rejection

Correlation of electrocardiographic abnormalities occurring postoperatively with lesions of the conduction system found at autopsy was done in 20 dogs which had received cardiac homografts. The incidence of arrhythmias closely paralleled the severity of rejection injury found within the heart and sp...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1969-05, Vol.39 (5), p.567-575
Main Authors: Bieber, C P, Stinson, E B, Shumway, N E
Format: Article
Language:English
Subjects:
Animals
Antilymphocyte Serum
Arrhythmias, Cardiac - etiology
Arrhythmias, Cardiac - pathology
Azathioprine - pharmacology
Dogs
Electrocardiography
Heart Conduction System - pathology
Heart Conduction System - physiopathology
Heart Transplantation
Immunosuppressive Agents - pharmacology
Prednisolone - pharmacology
Transplantation Immunology
Transplantation, Homologous
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Correlation of electrocardiographic abnormalities occurring postoperatively with lesions of the conduction system found at autopsy was done in 20 dogs which had received cardiac homografts. The incidence of arrhythmias closely paralleled the severity of rejection injury found within the heart and specifically within the conduction system. Severe pathological changes in the conduction system (grade D) were uniformly associated with arrhythmias. These disturbances, as well as decrease in electrocardiographic voltage, have consistent anatomic correlates in acute rejection of cardiac homografts and are of primary importance in the clinical diagnosis of acute rejection.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.39.5.567