DEPRESSOR RESPONSE TO NORADRENALINE IN HYPOTHERMIC CATS

Although noradrenaline (NA) is well known for its pressor effect, it has been shown to produce a depressor response in hypothermic cats and dogs (1, 2) ; the mechanism of the latter effect has, however, not yet been clearly elucidated. This effect has been attributed to its ganglion blocking action...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1969, Vol.19(1), pp.68-73
Main Authors: KAR, K., SUR, R.N., PRADHAN, S.N.
Format: Article
Language:English
Subjects:
Acetazolamide - pharmacology
Acetylcholine - pharmacology
Animals
Atropine - pharmacology
Bicarbonates - pharmacology
Blood Pressure - drug effects
Calcium - pharmacology
Cats
Depression, Chemical
Electrocardiography
Epinephrine - pharmacology
Female
Gluconates
Guanethidine - pharmacology
Hexamethonium Compounds - pharmacology
Hypothermia
Isoproterenol - pharmacology
Lactates - pharmacology
Male
Neostigmine - pharmacology
Norepinephrine - pharmacology
Phenoxybenzamine - pharmacology
Phentolamine - pharmacology
Physostigmine - pharmacology
Pituitary Hormones, Posterior - pharmacology
Potassium Chloride - pharmacology
Tolazoline - pharmacology
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Summary:Although noradrenaline (NA) is well known for its pressor effect, it has been shown to produce a depressor response in hypothermic cats and dogs (1, 2) ; the mechanism of the latter effect has, however, not yet been clearly elucidated. This effect has been attributed to its ganglion blocking action (1) as well as to the parasympathetic over-activity resulting from the altered state of the higher autonomic center during hypothermia (2). It was, therefore, the object of this study to investigate further the mechanism of this depressor response to NA during hypothermia.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.19.68