Long-term effects of clofibrate (Atromid-S) on serum lipids in man

Clofibrate was administered to 45 patients for varying periods of time up to 4 years with no evidence of chronic toxicity. Clofibrate was more effective in lowering serum triglycerides than serum cholesterol, with more than 75% of all patients with elevated triglycerides having at least a 25% reduct...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1969-05, Vol.39 (5), p.675-684
Main Authors: Hunninghake, D B, Tucker, D R, Azarnoff, D L
Format: Article
Language:English
Subjects:
Adult
Aged
Anticholesteremic Agents - administration & dosage
Anticholesteremic Agents - adverse effects
Butyrates - administration & dosage
Cholesterol - blood
Female
Humans
Hypercholesterolemia - drug therapy
Hyperlipidemias - drug therapy
Male
Middle Aged
Time Factors
Triglycerides - blood
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Summary:Clofibrate was administered to 45 patients for varying periods of time up to 4 years with no evidence of chronic toxicity. Clofibrate was more effective in lowering serum triglycerides than serum cholesterol, with more than 75% of all patients with elevated triglycerides having at least a 25% reduction in triglycerides, the absolute reduction in triglycerides being directly correlated with pretreatment values. A reduction in serum cholesterol of 15% or more was obtained in 50% of all patients, those individuals with elevations of triglycerides having the greatest reduction in serum cholesterol as well as being most likely to respond.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.39.5.675