Sleep: Suppression of Rapid Eye Movement Phase in the Cat after Electroconvulsive Shock

Electroconvulsive shock, administered for 5 to 7 days, reduced the daily rapid eye movement sleep time of seven cats to as little as 28 percent of base line levels. After day 4, eye movements during periods of cortical activation without tonic electromyographic activity were greatly reduced. Althoug...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1966-10, Vol.154 (3747), p.396-398
Main Authors: Cohen, Harry B., Dement, William C.
Format: Article
Language:English
Subjects:
Animals
Cats
Convulsions
Electroconvulsive Therapy
Ethyl Ethers - pharmacology
Eye Movements
Female
Hemoglobins
In rem
Intravenous injections
Male
Pentylenetetrazole - pharmacology
Phenotypes
Rapid eye movement sleep
Sleep
Sleep deprivation
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Summary:Electroconvulsive shock, administered for 5 to 7 days, reduced the daily rapid eye movement sleep time of seven cats to as little as 28 percent of base line levels. After day 4, eye movements during periods of cortical activation without tonic electromyographic activity were greatly reduced. Although partially deprived of rapid eye movements for as long as 7 days, the cats showed no compensatory rise in rapid eye movement time during the recovery period, but controls equally deprived gave significant rebounds. Rapid eye movement time of anesthetized cats was not affected by current that usually produces convulsions; it was lowered in animals convulsed with metrazol, but the same dosage of this drug, administered so as to avoid convulsions, had little effect. It appears that some aspect of the convulsion is responsible for lowering the rapid eye movement time.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.154.3747.396