Beta-1C-Globulin: Metabolism in Glomerulonephritis

The metabolism of $\beta $ $_{1C}$-globulin labeled with iodine-131 was studied in six normal individuals and in three individuals with glomerulonephritis who exhibited markedly reduced serum concentrations of this protein. Fractional catabolic rates were similar in both groups, and therefore the lo...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1966-07, Vol.153 (3732), p.180-182
Main Authors: Alper, Chester A., Levin, Alan S., Rosen, Fred S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antiserum
Blood
Blood plasma
Child
DNA
Female
Germination
Globulins
Glomerulonephritis
Glomerulonephritis - metabolism
Humans
In Vitro Techniques
Iodine Isotopes
Male
Radioactive decay
RNA
Spores
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Summary:The metabolism of $\beta $ $_{1C}$-globulin labeled with iodine-131 was studied in six normal individuals and in three individuals with glomerulonephritis who exhibited markedly reduced serum concentrations of this protein. Fractional catabolic rates were similar in both groups, and therefore the low concentration of serum $\beta $ $_{1C}$-globulin in glomerulonephritis appears to be chiefly secondary to decreased synthesis.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.153.3732.180