Diabetes, a New Mutation in the Mouse

Diabetes (db), which occurred in an inbred strain of mouse, is inherited as a unit autosomal recessive and is characterized by a metabolic disturbance resembling diabetes mellitus in man. Abnormal deposition of fat at 3 to 4 weeks of age is followed shortly by hyperglycemia, polyuria, and glycosuria...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1966-09, Vol.153 (3740), p.1127-1128
Main Authors: Hummel, Katharine P., Dickie, Margaret M., Coleman, Douglas L.
Format: Article
Language:English
Subjects:
Animals
Blood Glucose
Body Weight
Diabetes
Diabetes complications
Diabetes mellitus
Diabetes Mellitus - genetics
Esters
Female
Homozygotes
Inbred strains
Male
Mice
Mutation
Obesity
Ovaries
Sugars
Urine
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Summary:Diabetes (db), which occurred in an inbred strain of mouse, is inherited as a unit autosomal recessive and is characterized by a metabolic disturbance resembling diabetes mellitus in man. Abnormal deposition of fat at 3 to 4 weeks of age is followed shortly by hyperglycemia, polyuria, and glycosuria. Accompanying morphological changes in the islets of Langerhans suggest neogenesis to compensate for insulin depletion.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.153.3740.1127