Moloney Leukaemia Virus as a Helper in retrieving Friend Virus from a Non-infectious Reticulum Cell Sarcoma

A TRANSPLANTABLE reticulum cell sarcoma induced by Friend virus (FV) and subsequently grown in tissue culture no longer contained detectable infectious FV, and was incapable of inducing either protective or viral neutralizing antibodies 1,2 . This tumour (FVTCT) has been maintained in vitro for seve...

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Bibliographic Details
Published in:Nature (London) 1969-09, Vol.223 (5212), p.1274-1274
Main Authors: FIELDSTEEL, A. HOWARD, KURAHARA, CAROLE, DAWSON, PETER J.
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Friend murine leukemia virus - isolation & purification
Helper Viruses
Humanities and Social Sciences
letter
Leukemia, Experimental - microbiology
Lymphoma, Non-Hodgkin - microbiology
Mice
Moloney murine leukemia virus
multidisciplinary
Neoplasm Transplantation
Sarcoma, Experimental - microbiology
Science
Science (multidisciplinary)
Virus Cultivation
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Description
Summary:A TRANSPLANTABLE reticulum cell sarcoma induced by Friend virus (FV) and subsequently grown in tissue culture no longer contained detectable infectious FV, and was incapable of inducing either protective or viral neutralizing antibodies 1,2 . This tumour (FVTCT) has been maintained in vitro for several years, and except for its apparent lack of virus it behaves in an identical way to the tumour from which it originated 3 . It is highly specific for syngeneic BALB/c mice and produces tumours morphologically indistinguishable from other reticulum cell sarcomas induced by FV.
ISSN:0028-0836
1476-4687
DOI:10.1038/2231274a0