Interaction of Cortex and Superior Colliculus in Mediation of Visually Guided Behavior in the Cat

Total contralateral hemianopia follows unilateral removal of the entire occipito-temporal neocortex in the cat. This deficit is classically ascribed to interruption of visual radiations serving cortical function ("cortical blindness") and is considered permanent. Return of vision to the he...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1966-09, Vol.153 (3743), p.1544-1547
Main Author: Sprague, James M.
Format: Article
Language:English
Subjects:
Amnesia
Anatomy
Animals
Behavior, Animal
Cats
Cerebral Cortex - physiology
Hemianopia
Hemianopsia - physiopathology
Lesions
Mental stimulation
Midbrain
Spinal cord
Superior colliculus
Tectum Mesencephali - physiology
Visual cortex
Visual Fields
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Summary:Total contralateral hemianopia follows unilateral removal of the entire occipito-temporal neocortex in the cat. This deficit is classically ascribed to interruption of visual radiations serving cortical function ("cortical blindness") and is considered permanent. Return of vision to the hemianopic field after subsequent removal of the superior colliculus contralateral to the cortical lesion demonstrates that neither assumption is correct. The initial hemianopia is apparently due to depression of function of the colliculus ipsilateral to the cortical lesion, a depression maintained by influx of inhibition from the crossed colliculus. Thus, removal of the contralateral tectum, or splitting of the collicular commissure, abolishes this inhibition and allows the return of function in the ipsilateral colliculus, and with it the recovery from hemianopia. These findings emphasize that visually guided behavior is mediated at both cortical and midbrain levels, and that there is a marked interaction between these sites.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.153.3743.1544