Surfactant-Base-Barbiturate Suppositories I: Rectal Absorption in Rabbits

A series of pet rolatum-paraffin-surfactant suppository bases were tested in rabbits under carefully controlled conditions with a series of barbiturates included. Each surfactant had a different HLB value and each barbiturate had a different distribution coefficient. The depression of the respirator...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1966-01, Vol.55 (1), p.23-28
Main Authors: Fincher, J.H., Entrekln, D.N., Hartman, C.W.
Format: Article
Language:English
Subjects:
Absorption
Animals
Barbiturates - metabolism
Drug Compounding
Male
Rabbits
Suppositories
Surface-Active Agents - pharmacology
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Summary:A series of pet rolatum-paraffin-surfactant suppository bases were tested in rabbits under carefully controlled conditions with a series of barbiturates included. Each surfactant had a different HLB value and each barbiturate had a different distribution coefficient. The depression of the respiratory rate was measured for a period of 2.5hr. to det ermine absorption rates. A comparative analysis of the data is presented. The effects of the chemical type of the drug and the surfactant are shown in the comparative studies. Surfactants enhanced the release and absorption of the barbiturate in some bases; however, binding of the drug is suspected in some bases. The relationships of the HLB of the surfactant and the distribution coefficient of the drug to release and absorption are presented. Further work, using different approaches to this problem, is indicated.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600550105