An analysis of the ABO blood group clines in Europe

With estimates of the fitnesses of the genotypes and selection by incompatibility for the ABO locus which seem reasonable given the state of knowledge, a computer model has been developed to replicate the clines of the A and B genes in Europe. With a fitness change in the BB and BO genotypes of as l...

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Bibliographic Details
Published in:American journal of physical anthropology 1969-07, Vol.31 (1), p.1-9
Main Author: Livingstone, Frank B.
Format: Article
Language:English
Subjects:
ABO Blood-Group System
Blood Group Antigens
Computers
Europe
Female
Gene Frequency
Genes
Genetics, Medical
Genetics, Population
Genotype
Humans
Male
Models, Biological
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Summary:With estimates of the fitnesses of the genotypes and selection by incompatibility for the ABO locus which seem reasonable given the state of knowledge, a computer model has been developed to replicate the clines of the A and B genes in Europe. With a fitness change in the BB and BO genotypes of as little as 0.5%, the differences in the frequencies in East and West Europe can be maintained at equilibrium. Appreciable changes in the amount of migration does not affect the equilibrium frequencies in the two areas significantly, while with no selection through incompatibility the equilibrium frequencies were changed about 5%.
ISSN:0002-9483
1096-8644
DOI:10.1002/ajpa.1330310102