Proton Transfer Processes in Muscle : Pressure, Temperature and Isotope Effects

INVESTIGATIONS of muscular contraction in heavy water have shown that the rate-determining process involves proton transfer 1 . The magnitude of the effect suggests that more than one proton is involved. Varga 2 has observed that fibres under isometric tension in the presence of adenosine triphospha...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 1966-01, Vol.209 (5018), p.82-83
Main Authors: HORNE, R. A, JOHNSON, D. S
Format: Article
Language:English
Subjects:
Humanities and Social Sciences
In Vitro Techniques
letter
multidisciplinary
Muscle Contraction - physiology
Pressure
Protons
Science
Science (multidisciplinary)
Temperature
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:INVESTIGATIONS of muscular contraction in heavy water have shown that the rate-determining process involves proton transfer 1 . The magnitude of the effect suggests that more than one proton is involved. Varga 2 has observed that fibres under isometric tension in the presence of adenosine triphosphate are relaxed when the temperature is lowered, an effect which has been attributed to the endothermicity of actomyosin formation. On the other hand, increasing the hydrostatic pressure results in contraction of intact muscle 3–5 .
ISSN:0028-0836
1476-4687
DOI:10.1038/209082a0