RESPONSE OF THE NEWBORN RABBIT TO ACUTE ANOXIA AND VARIATIONS DUE TO NARCOTIC AGENTS

Newborn rabbits were rendered acutely anoxic by insertion into an atmosphere of nitrogen and their respiratory movements were recorded by direct observation and by an impedance pneumograph. The respiratory response comprised periods of dyspnoea, preterminal apnoea, gasping, and terminal apnoea. The...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1966-10, Vol.38 (10), p.787-793
Main Authors: MOORE, W.M.O., DAVIS, J.A.
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Apnea - physiopathology
Body Weight
Dyspnea - physiopathology
Hypoxia - physiopathology
Levallorphan - pharmacology
Meperidine - pharmacology
Morphine - pharmacology
Nalorphine - pharmacology
Rabbits
Respiratory Function Tests - instrumentation
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Summary:Newborn rabbits were rendered acutely anoxic by insertion into an atmosphere of nitrogen and their respiratory movements were recorded by direct observation and by an impedance pneumograph. The respiratory response comprised periods of dyspnoea, preterminal apnoea, gasping, and terminal apnoea. The duration of preterminal apnoea was increased at the expense of the period of gasping by the prior administration of morphine or pethidine in a dosage insufficient to cause important respiratory depression in air, survival not being shortened.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/38.10.787