Red Cell Lipids in Autoimmune Hemolytic Anemia

The content of total cholesterol, phospholipids and individual phospholipid fractions was examined in red blood cells in autoimmune hemolytic anemia. In the period of increased hemolysis, red cells of patients with this disease with sensitization of the gamma type contained significantly less choles...

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Bibliographic Details
Published in:Blood 1969-10, Vol.34 (4), p.414-420
Main Authors: Brabec, V., Michalec, Č., Palek, J., Kout, M.
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Anemia, Hemolytic, Autoimmune - blood
Anemia, Hemolytic, Autoimmune - drug therapy
Anemia, Hemolytic, Autoimmune - immunology
Antibodies, Anti-Idiotypic - analysis
Antigens
Cholesterol - blood
Erythrocytes - analysis
Erythrocytes - immunology
Hemolysis
Humans
Neutralization Tests
Phosphatidylcholines - blood
Phosphatidylethanolamines - blood
Phospholipids - blood
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Description
Summary:The content of total cholesterol, phospholipids and individual phospholipid fractions was examined in red blood cells in autoimmune hemolytic anemia. In the period of increased hemolysis, red cells of patients with this disease with sensitization of the gamma type contained significantly less cholesterol and phospholipids per single cell. The relative distribution of the individual phospholipid fractions remained unchanged. Patients with this disease with sensitization of the non-gamma type and patients in a remission of the disease did not show any of these changes.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V34.4.414.414