Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice

Neonatal thymectomy of mice, when no ectopic thymus existed, constantly resulted in developmental arrest of the ovary but not of the testis; it also caused sterility in the female. The ovaries of thymectomized mice were extremely small and were characterized by absence of follicles and corpora lutea...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1969-11, Vol.166 (3906), p.753-755
Main Authors: Nishizuka, Yasuaki, Sakakura, Teruyo
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Autopsies
Female
Follicles
Gonads
Histology
Infertility, Female - etiology
Male
Mice
Ovaries
Ovary
Thymectomy
Thymus Gland - physiology
Thymus Gland - transplantation
Transplantation immunology
Uterus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neonatal thymectomy of mice, when no ectopic thymus existed, constantly resulted in developmental arrest of the ovary but not of the testis; it also caused sterility in the female. The ovaries of thymectomized mice were extremely small and were characterized by absence of follicles and corpora lutea. Such an ovarian dysgenesia was observed when the mice were thymectomized at 3 days of age, but not at 7 days or later; it was prevented by thymus grafting.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.166.3906.753