EFFECT OF SEX HORMONES ON THE THIORIDAZINE-INDUCED INHIBITION OF CONDITIONED AVOIDANCE RESPONSE IN THE RAT

In the preceding paper, it was shown that the rat became tolerant to some psychotropic drugs when blockage of the conditioned avoidance response was estimated as an index of tranquillizing activity (1). In the course of these studies, a statistically significant difference was obtained between male...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1966/06/01, Vol.16(2), pp.198-203
Main Authors: MATSUKI, KATSUHIKO, IWAMOTO, TAKIO
Format: Article
Language:English
Subjects:
Animals
Avoidance Learning - drug effects
Castration
Conditioning (Psychology) - drug effects
Estradiol - pharmacology
Female
Male
Rats
Testosterone - pharmacology
Thioridazine - pharmacology
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Summary:In the preceding paper, it was shown that the rat became tolerant to some psychotropic drugs when blockage of the conditioned avoidance response was estimated as an index of tranquillizing activity (1). In the course of these studies, a statistically significant difference was obtained between male and female rats in the development of tolerance upon the repeated administration of chlordiazepoxide and thioridazine. The purpose of the present study was to determine whether sex hormones are primarily concerned with this apparent sex difference in the development of the drug tolerance.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.16.198