Rate of Fixation of Nucleotide Substitutions in Evolution

Nucleotide sequences of rodents and of artiodactyls have been compared by DNA/DNA duplex formation. The rate of evolution in terms of fixation of nucleotide substitutions inferred from non-repeated artiodactyl DNAs is three times greater than that inferred from comparative amino-acid sequence of the...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 1969-10, Vol.224 (5215), p.149-154
Main Authors: LAIRD, CHARLES D, McCONAUGHY, BETTY L, McCARTHY, BRIAN J
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Biological Evolution
Cattle
Cricetinae
DNA
Genetic Code
Genetic Variation
Guinea Pigs
Hemoglobins
Humanities and Social Sciences
L Cells (Cell Line)
Mice
multidisciplinary
Nucleic Acid Denaturation
Nucleotides
Rats
Science
Science (multidisciplinary)
Sheep
Space life sciences
Species Specificity
Swine
Temperature
Time Factors
Tritium
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nucleotide sequences of rodents and of artiodactyls have been compared by DNA/DNA duplex formation. The rate of evolution in terms of fixation of nucleotide substitutions inferred from non-repeated artiodactyl DNAs is three times greater than that inferred from comparative amino-acid sequence of the α and β chains of haemoglobin from these same organisms. The initial rate of nucleotide sequence variation among rodents is ten-fold higher than that among artiodactyls when divergence time is estimated in years. This difference diminishes if generations, rather than years, represent the appropriate interval of evolutionary divergence.
ISSN:0028-0836
1476-4687
DOI:10.1038/224149a0