Studies on Vitamin B12 Status in Blood and Tissue of Alloxan Diabetic Animals

Studies were performed to find out the vitamin B12 status in blood tissues of alloxan diabetic animals. It was found that diabetic animals maintaining higher levels of blood ketone bodies had an increased requirement of vitamin B12. The maximum requirement for the vitamin was found in diabetic anima...

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Bibliographic Details
Published in:Journal of vitaminology 1969/06/10, Vol.15(2), pp.174-177
Main Authors: NATH, N., NATH, M. C.
Format: Article
Language:English
Subjects:
Acetoacetates - metabolism
Animals
Blood Glucose - analysis
Diabetes Mellitus, Experimental - metabolism
DNA - metabolism
Injections, Subcutaneous
Ketone Bodies - blood
Kidney - metabolism
Liver - metabolism
Male
Proteins - metabolism
Rats
RNA - metabolism
Sulfhydryl Compounds - metabolism
Vitamin B 12 - blood
Vitamin B 12 - metabolism
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Summary:Studies were performed to find out the vitamin B12 status in blood tissues of alloxan diabetic animals. It was found that diabetic animals maintaining higher levels of blood ketone bodies had an increased requirement of vitamin B12. The maximum requirement for the vitamin was found in diabetic animals getting a higher dose of acetoacetate. Hepatic constituents also changed adversely in order of level of ketone bodies in the diabetic animals. Some direct or indirect interrelationship between vitamin B12 with ketone bodies are suggested.
ISSN:0022-5398
DOI:10.5925/jnsv1954.15.174