The Effect of Lithium Carbonate on the Electroencephalogram of Patients with Affective Disorders

This paper examines the degree of electroencephalogram abnormality among the three phases of manic-depressive disease and the changes brought about by lithium carbonate. The earlier investigators (Berger, 1931; Lemere, 1936) reported no abnormalities in the EEGs of manic-depressive patients. Later w...

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Bibliographic Details
Published in:British journal of psychiatry 1969-10, Vol.115 (527), p.1185-1188
Main Authors: Platman, S. R., Fieve, R. R.
Format: Article
Language:English
Subjects:
Adult
Bipolar Disorder - drug therapy
Chlorpromazine - pharmacology
Clinical Trials as Topic
Electroencephalography
Female
Humans
Imipramine - pharmacology
Lithium - blood
Lithium - therapeutic use
Male
Middle Aged
Placebos
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Summary:This paper examines the degree of electroencephalogram abnormality among the three phases of manic-depressive disease and the changes brought about by lithium carbonate. The earlier investigators (Berger, 1931; Lemere, 1936) reported no abnormalities in the EEGs of manic-depressive patients. Later workers (Davis, 1941; Hurst et al., 1954; Hes, 1960) found prominent changes between the two phases. However, Harding et al. (1966) noted no common pattern in their three cases when analysed for mean abundance, harmonic mean and variability of alpha rhythm.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.115.527.1185