Effect of Bacitracin on in vitro Phagocytosis

PREVIOUS investigations of the influence of antimicrobial compounds on phagocytosis indicated that polypeptide antibiotics like bacitracin and polymyxin B retarded ingestion of polystyrene latex (PSL) particles or Staphylococcus aureus by guinea-pig polymorphonuclear leucocytes (PMN) 1 . Although th...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 1966-05, Vol.210 (5036), p.654-656
Main Authors: DOWNEY, R. J, PISANO, J. C
Format: Article
Language:English
Subjects:
Bacitracin - pharmacology
Humanities and Social Sciences
letter
multidisciplinary
Phagocytosis - drug effects
Science
Science (multidisciplinary)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:PREVIOUS investigations of the influence of antimicrobial compounds on phagocytosis indicated that polypeptide antibiotics like bacitracin and polymyxin B retarded ingestion of polystyrene latex (PSL) particles or Staphylococcus aureus by guinea-pig polymorphonuclear leucocytes (PMN) 1 . Although the levels of antibiotic necessary to produce this inhibition exceeded the therapeutic level for the guinea-pig, it was of interest to discern the mode of action of this peptide on the ingestion process and possibly gain further insight as to the basic mechanism of phagocytosis. This communication embodies some of the evidence for the chelating effect of the peptide and the essential participation of metal ions in phagocytosis.
ISSN:0028-0836
1476-4687
DOI:10.1038/210654a0