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Effect of Bacitracin on in vitro Phagocytosis
PREVIOUS investigations of the influence of antimicrobial compounds on phagocytosis indicated that polypeptide antibiotics like bacitracin and polymyxin B retarded ingestion of polystyrene latex (PSL) particles or Staphylococcus aureus by guinea-pig polymorphonuclear leucocytes (PMN) 1 . Although th...
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| Published in: | Nature (London) 1966-05, Vol.210 (5036), p.654-656 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c312t-96837edfae05841bea73369e6211d7154c573ed09eddda9e914a0036c869c6e73 |
| container_end_page | 656 |
| container_issue | 5036 |
| container_start_page | 654 |
| container_title | Nature (London) |
| container_volume | 210 |
| creator | DOWNEY, R. J. PISANO, J. C. |
| description | PREVIOUS investigations of the influence of antimicrobial compounds on phagocytosis indicated that polypeptide antibiotics like bacitracin and polymyxin
B
retarded ingestion of polystyrene latex (PSL) particles or
Staphylococcus aureus
by guinea-pig polymorphonuclear leucocytes (PMN)
1
. Although the levels of antibiotic necessary to produce this inhibition exceeded the therapeutic level for the guinea-pig, it was of interest to discern the mode of action of this peptide on the ingestion process and possibly gain further insight as to the basic mechanism of phagocytosis. This communication embodies some of the evidence for the chelating effect of the peptide and the essential participation of metal ions in phagocytosis. |
| doi_str_mv | 10.1038/210654a0 |
| format | article |
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B
retarded ingestion of polystyrene latex (PSL) particles or
Staphylococcus aureus
by guinea-pig polymorphonuclear leucocytes (PMN)
1
. Although the levels of antibiotic necessary to produce this inhibition exceeded the therapeutic level for the guinea-pig, it was of interest to discern the mode of action of this peptide on the ingestion process and possibly gain further insight as to the basic mechanism of phagocytosis. This communication embodies some of the evidence for the chelating effect of the peptide and the essential participation of metal ions in phagocytosis.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/210654a0</identifier><identifier>PMID: 5964586</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Bacitracin - pharmacology ; Humanities and Social Sciences ; letter ; multidisciplinary ; Phagocytosis - drug effects ; Science ; Science (multidisciplinary)</subject><ispartof>Nature (London), 1966-05, Vol.210 (5036), p.654-656</ispartof><rights>Springer Nature Limited 1966</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c312t-96837edfae05841bea73369e6211d7154c573ed09eddda9e914a0036c869c6e73</citedby><cites>FETCH-LOGICAL-c312t-96837edfae05841bea73369e6211d7154c573ed09eddda9e914a0036c869c6e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5964586$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DOWNEY, R. J.</creatorcontrib><creatorcontrib>PISANO, J. C.</creatorcontrib><title>Effect of Bacitracin on in vitro Phagocytosis</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>PREVIOUS investigations of the influence of antimicrobial compounds on phagocytosis indicated that polypeptide antibiotics like bacitracin and polymyxin
B
retarded ingestion of polystyrene latex (PSL) particles or
Staphylococcus aureus
by guinea-pig polymorphonuclear leucocytes (PMN)
1
. Although the levels of antibiotic necessary to produce this inhibition exceeded the therapeutic level for the guinea-pig, it was of interest to discern the mode of action of this peptide on the ingestion process and possibly gain further insight as to the basic mechanism of phagocytosis. This communication embodies some of the evidence for the chelating effect of the peptide and the essential participation of metal ions in phagocytosis.</description><subject>Bacitracin - pharmacology</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>multidisciplinary</subject><subject>Phagocytosis - drug effects</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1966</creationdate><recordtype>article</recordtype><recordid>eNplkM1Lw0AQxRdRaq2C_4CQk-ghOpv9zFFL_YCCHvS8bDeTmtJm624i9L93pdGLlzcM78dj5hFyTuGGAtO3BQUpuIUDMqZcyZxLrQ7JGKDQOWgmj8lJjCsAEFTxERmJUnKh5Zjks7pG12W-zu6ta7qQpM18myX9SqvPXj_s0rtd52MTT8lRbdcRz4Y5Ie8Ps7fpUz5_eXye3s1zx2jR5aXUTGFVWwShOV2gVYzJEmVBaaWo4E4ohhWUWFWVLbGk6XRg0mlZOomKTcjlPncb_GePsTObJjpcr22Lvo9GcwZM8CKBV3vQBR9jwNpsQ7OxYWcomJ9mzG8zCb0YMvvFBqs_cKgi-dd7PyanXWIwK9-HNr35P-sbtWRo7g</recordid><startdate>19660507</startdate><enddate>19660507</enddate><creator>DOWNEY, R. J.</creator><creator>PISANO, J. C.</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19660507</creationdate><title>Effect of Bacitracin on in vitro Phagocytosis</title><author>DOWNEY, R. J. ; PISANO, J. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c312t-96837edfae05841bea73369e6211d7154c573ed09eddda9e914a0036c869c6e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1966</creationdate><topic>Bacitracin - pharmacology</topic><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>multidisciplinary</topic><topic>Phagocytosis - drug effects</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DOWNEY, R. J.</creatorcontrib><creatorcontrib>PISANO, J. C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DOWNEY, R. J.</au><au>PISANO, J. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Bacitracin on in vitro Phagocytosis</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1966-05-07</date><risdate>1966</risdate><volume>210</volume><issue>5036</issue><spage>654</spage><epage>656</epage><pages>654-656</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>PREVIOUS investigations of the influence of antimicrobial compounds on phagocytosis indicated that polypeptide antibiotics like bacitracin and polymyxin
B
retarded ingestion of polystyrene latex (PSL) particles or
Staphylococcus aureus
by guinea-pig polymorphonuclear leucocytes (PMN)
1
. Although the levels of antibiotic necessary to produce this inhibition exceeded the therapeutic level for the guinea-pig, it was of interest to discern the mode of action of this peptide on the ingestion process and possibly gain further insight as to the basic mechanism of phagocytosis. This communication embodies some of the evidence for the chelating effect of the peptide and the essential participation of metal ions in phagocytosis.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>5964586</pmid><doi>10.1038/210654a0</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1966-05, Vol.210 (5036), p.654-656 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84303542 |
| source | Nature Journals |
| subjects | Bacitracin - pharmacology Humanities and Social Sciences letter multidisciplinary Phagocytosis - drug effects Science Science (multidisciplinary) |
| title | Effect of Bacitracin on in vitro Phagocytosis |
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