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Effects of Chlorpheniramine and Pyrilamine on the Atrial Actions of Acetylcholine, Tyramine, and Ephedrine
The experiments described herein were performed on isolated, spontaneously beating rabbit atria. The muscarinic actions of acetylcholine in the presence of physostigmine were antagonized by pyrilamine, chlorpheniramine and procaine which demonstrates that these drugs have an “antimuscarinic” action....
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| Published in: | Journal of pharmaceutical sciences 1969-11, Vol.58 (11), p.1313-1318 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c4274-58c929a376efa728a7096f86925b63d18656f34501faee8035c1e2cfe356cd8d3 |
| container_end_page | 1318 |
| container_issue | 11 |
| container_start_page | 1313 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 58 |
| creator | Osterberg, Robert E. Koppanyi, Theodore |
| description | The experiments described herein were performed on isolated, spontaneously beating rabbit atria. The muscarinic actions of acetylcholine in the presence of physostigmine were antagonized by pyrilamine, chlorpheniramine and procaine which demonstrates that these drugs have an “antimuscarinic” action. The nicotinic (positive inotropic and chronotropic) actions of acetylcholine in the presence of atropine were also antagonized by pyrilamine and chlorpheniramine. Cocaine, pyrilamine, and chlorpheniramine inhibited the atrial stimulation by tyramine and ephedrine. The fact that the antimuscarinic and antinicotinic effects of pyrilamine and chlorpheniramine show similar slopes may indicate that similar receptors are involved. Cocaine and pyrilamine also have parallel slopes indicating that pyrilamine has a cocaine-like effect which is not related to local anesthesia. |
| doi_str_mv | 10.1002/jps.2600581104 |
| format | article |
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The muscarinic actions of acetylcholine in the presence of physostigmine were antagonized by pyrilamine, chlorpheniramine and procaine which demonstrates that these drugs have an “antimuscarinic” action. The nicotinic (positive inotropic and chronotropic) actions of acetylcholine in the presence of atropine were also antagonized by pyrilamine and chlorpheniramine. Cocaine, pyrilamine, and chlorpheniramine inhibited the atrial stimulation by tyramine and ephedrine. The fact that the antimuscarinic and antinicotinic effects of pyrilamine and chlorpheniramine show similar slopes may indicate that similar receptors are involved. Cocaine and pyrilamine also have parallel slopes indicating that pyrilamine has a cocaine-like effect which is not related to local anesthesia.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600581104</identifier><identifier>PMID: 5349741</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Acetylcholine - antagonists & inhibitors ; Animals ; Antimuscarinic activity-chlorpheniramine ; Antimuscarinic activity—chlorpheniramine, pyrilamine, procaine ; Antinicotinic activity-chlorpheniramine ; Antinicotinic activity—chlorpheniramine, pyrilamine, cocaine ; Atrial depression-acetylcholine ; Atrial depression–acetylcholine, physostigmine produced ; Atropine - pharmacology ; Chlorpheniramine ; Chlorpheniramine - pharmacology ; Chlorpheniramine, pyrilamine, procaine effect—induced atrial depression ; cocaine ; Cocaine - pharmacology ; cocaine effect ; Ephedrine - antagonists & inhibitors ; ephedrine atrial stimulation-chlorpheniramine ; Heart - drug effects ; Heart Atria - drug effects ; Heart Rate - drug effects ; In Vitro Techniques ; Male ; Muscle Contraction - drug effects ; Physostigmine - pharmacology ; physostigmine produced ; procaine ; Procaine - pharmacology ; procaine effect-induced atrial depression ; pyrilamine ; Pyrroles - pharmacology ; Rabbits ; Receptors, Drug - drug effects ; Time Factors ; Tyramine ; Tyramine - antagonists & inhibitors ; Tyramine, ephedrine atrial stimulation—chlorpheniramine, pyrilamine, cocaine effect</subject><ispartof>Journal of pharmaceutical sciences, 1969-11, Vol.58 (11), p.1313-1318</ispartof><rights>1969 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4274-58c929a376efa728a7096f86925b63d18656f34501faee8035c1e2cfe356cd8d3</citedby><cites>FETCH-LOGICAL-c4274-58c929a376efa728a7096f86925b63d18656f34501faee8035c1e2cfe356cd8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600581104$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600581104$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5349741$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Osterberg, Robert E.</creatorcontrib><creatorcontrib>Koppanyi, Theodore</creatorcontrib><title>Effects of Chlorpheniramine and Pyrilamine on the Atrial Actions of Acetylcholine, Tyramine, and Ephedrine</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>The experiments described herein were performed on isolated, spontaneously beating rabbit atria. The muscarinic actions of acetylcholine in the presence of physostigmine were antagonized by pyrilamine, chlorpheniramine and procaine which demonstrates that these drugs have an “antimuscarinic” action. The nicotinic (positive inotropic and chronotropic) actions of acetylcholine in the presence of atropine were also antagonized by pyrilamine and chlorpheniramine. Cocaine, pyrilamine, and chlorpheniramine inhibited the atrial stimulation by tyramine and ephedrine. The fact that the antimuscarinic and antinicotinic effects of pyrilamine and chlorpheniramine show similar slopes may indicate that similar receptors are involved. Cocaine and pyrilamine also have parallel slopes indicating that pyrilamine has a cocaine-like effect which is not related to local anesthesia.</description><subject>Acetylcholine - antagonists & inhibitors</subject><subject>Animals</subject><subject>Antimuscarinic activity-chlorpheniramine</subject><subject>Antimuscarinic activity—chlorpheniramine, pyrilamine, procaine</subject><subject>Antinicotinic activity-chlorpheniramine</subject><subject>Antinicotinic activity—chlorpheniramine, pyrilamine, cocaine</subject><subject>Atrial depression-acetylcholine</subject><subject>Atrial depression–acetylcholine, physostigmine produced</subject><subject>Atropine - pharmacology</subject><subject>Chlorpheniramine</subject><subject>Chlorpheniramine - pharmacology</subject><subject>Chlorpheniramine, pyrilamine, procaine effect—induced atrial depression</subject><subject>cocaine</subject><subject>Cocaine - pharmacology</subject><subject>cocaine effect</subject><subject>Ephedrine - antagonists & inhibitors</subject><subject>ephedrine atrial stimulation-chlorpheniramine</subject><subject>Heart - drug effects</subject><subject>Heart Atria - drug effects</subject><subject>Heart Rate - drug effects</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Muscle Contraction - drug effects</subject><subject>Physostigmine - pharmacology</subject><subject>physostigmine produced</subject><subject>procaine</subject><subject>Procaine - pharmacology</subject><subject>procaine effect-induced atrial depression</subject><subject>pyrilamine</subject><subject>Pyrroles - pharmacology</subject><subject>Rabbits</subject><subject>Receptors, Drug - drug effects</subject><subject>Time Factors</subject><subject>Tyramine</subject><subject>Tyramine - antagonists & inhibitors</subject><subject>Tyramine, ephedrine atrial stimulation—chlorpheniramine, pyrilamine, cocaine effect</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><recordid>eNqFkUtvEzEURi1EVdLClh3SrFh1Uj_Gj1mGKBSqqlSiwNJyPdeKgzMO9gQ6_x7TiYq6QKysq3u-I_m7CL0meE4wpuebXZ5TgTFXhODmGZoRTnEtMJHP0awAtGa8aV-gk5w3GGOBOT9Gx5w1rWzIDG1WzoEdchVdtVyHmHZr6H0yW99DZfquuhmTD9MY-2pYQ7UYkjehWtjBx_4huLAwjMGuYyjYWXU7TvmzB8GqGLtUxpfoyJmQ4dXhPUVf3q9ulx_qq08XH5eLq9o2VDY1V7alrWFSgDOSKiNxK5wSLeV3gnVECS4cazgmzgAozLglQK0DxoXtVMdO0dvJu0vxxx7yoLc-WwjB9BD3WauGYaYILuB8Am2KOSdwepf81qRRE6z_lKtLufpvuSXw5mDe322he8QPbZZ9O-1_-QDjf2z68ubzE3c9ZX0e4P4xa9J3LSSTXH-7vtBLRujXd0Lq68KriYdS5U8PSWfrobfQ-VQOqrvo__WN3xGjp0g</recordid><startdate>196911</startdate><enddate>196911</enddate><creator>Osterberg, Robert E.</creator><creator>Koppanyi, Theodore</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196911</creationdate><title>Effects of Chlorpheniramine and Pyrilamine on the Atrial Actions of Acetylcholine, Tyramine, and Ephedrine</title><author>Osterberg, Robert E. ; Koppanyi, Theodore</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4274-58c929a376efa728a7096f86925b63d18656f34501faee8035c1e2cfe356cd8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Acetylcholine - antagonists & inhibitors</topic><topic>Animals</topic><topic>Antimuscarinic activity-chlorpheniramine</topic><topic>Antimuscarinic activity—chlorpheniramine, pyrilamine, procaine</topic><topic>Antinicotinic activity-chlorpheniramine</topic><topic>Antinicotinic activity—chlorpheniramine, pyrilamine, cocaine</topic><topic>Atrial depression-acetylcholine</topic><topic>Atrial depression–acetylcholine, physostigmine produced</topic><topic>Atropine - pharmacology</topic><topic>Chlorpheniramine</topic><topic>Chlorpheniramine - pharmacology</topic><topic>Chlorpheniramine, pyrilamine, procaine effect—induced atrial depression</topic><topic>cocaine</topic><topic>Cocaine - pharmacology</topic><topic>cocaine effect</topic><topic>Ephedrine - antagonists & inhibitors</topic><topic>ephedrine atrial stimulation-chlorpheniramine</topic><topic>Heart - drug effects</topic><topic>Heart Atria - drug effects</topic><topic>Heart Rate - drug effects</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Muscle Contraction - drug effects</topic><topic>Physostigmine - pharmacology</topic><topic>physostigmine produced</topic><topic>procaine</topic><topic>Procaine - pharmacology</topic><topic>procaine effect-induced atrial depression</topic><topic>pyrilamine</topic><topic>Pyrroles - pharmacology</topic><topic>Rabbits</topic><topic>Receptors, Drug - drug effects</topic><topic>Time Factors</topic><topic>Tyramine</topic><topic>Tyramine - antagonists & inhibitors</topic><topic>Tyramine, ephedrine atrial stimulation—chlorpheniramine, pyrilamine, cocaine effect</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Osterberg, Robert E.</creatorcontrib><creatorcontrib>Koppanyi, Theodore</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Osterberg, Robert E.</au><au>Koppanyi, Theodore</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Chlorpheniramine and Pyrilamine on the Atrial Actions of Acetylcholine, Tyramine, and Ephedrine</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1969-11</date><risdate>1969</risdate><volume>58</volume><issue>11</issue><spage>1313</spage><epage>1318</epage><pages>1313-1318</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>The experiments described herein were performed on isolated, spontaneously beating rabbit atria. The muscarinic actions of acetylcholine in the presence of physostigmine were antagonized by pyrilamine, chlorpheniramine and procaine which demonstrates that these drugs have an “antimuscarinic” action. The nicotinic (positive inotropic and chronotropic) actions of acetylcholine in the presence of atropine were also antagonized by pyrilamine and chlorpheniramine. Cocaine, pyrilamine, and chlorpheniramine inhibited the atrial stimulation by tyramine and ephedrine. The fact that the antimuscarinic and antinicotinic effects of pyrilamine and chlorpheniramine show similar slopes may indicate that similar receptors are involved. Cocaine and pyrilamine also have parallel slopes indicating that pyrilamine has a cocaine-like effect which is not related to local anesthesia.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>5349741</pmid><doi>10.1002/jps.2600581104</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1969-11, Vol.58 (11), p.1313-1318 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals |
| subjects | Acetylcholine - antagonists & inhibitors Animals Antimuscarinic activity-chlorpheniramine Antimuscarinic activity—chlorpheniramine, pyrilamine, procaine Antinicotinic activity-chlorpheniramine Antinicotinic activity—chlorpheniramine, pyrilamine, cocaine Atrial depression-acetylcholine Atrial depression–acetylcholine, physostigmine produced Atropine - pharmacology Chlorpheniramine Chlorpheniramine - pharmacology Chlorpheniramine, pyrilamine, procaine effect—induced atrial depression cocaine Cocaine - pharmacology cocaine effect Ephedrine - antagonists & inhibitors ephedrine atrial stimulation-chlorpheniramine Heart - drug effects Heart Atria - drug effects Heart Rate - drug effects In Vitro Techniques Male Muscle Contraction - drug effects Physostigmine - pharmacology physostigmine produced procaine Procaine - pharmacology procaine effect-induced atrial depression pyrilamine Pyrroles - pharmacology Rabbits Receptors, Drug - drug effects Time Factors Tyramine Tyramine - antagonists & inhibitors Tyramine, ephedrine atrial stimulation—chlorpheniramine, pyrilamine, cocaine effect |
| title | Effects of Chlorpheniramine and Pyrilamine on the Atrial Actions of Acetylcholine, Tyramine, and Ephedrine |
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