Cholinesterase Inhibitory Property of Dimethyl Sulphoxide

DIMETHYL sulphoxide (DMSO) has long been known for its solvent properties and its ability to prevent freezing damage to living cells 1 . More recently, it has been found to cross intact cellular membranes and the skin very readily and to effect rapid penetration through these tissues of some substan...

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Bibliographic Details
Published in:Nature (London) 1966-10, Vol.212 (5060), p.405-405
Main Authors: SAMS, W. MITCHELL, CARROLL, NICHOLAS V.
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Animals
Cholinesterase Inhibitors - pharmacology
Cholinesterases - metabolism
Diaphragm - drug effects
Dimethyl Sulfoxide - pharmacology
Guinea Pigs
Heart - drug effects
Heart Atria - drug effects
Heart Conduction System - drug effects
Humanities and Social Sciences
letter
multidisciplinary
Neostigmine - pharmacology
Science
Science (multidisciplinary)
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Description
Summary:DIMETHYL sulphoxide (DMSO) has long been known for its solvent properties and its ability to prevent freezing damage to living cells 1 . More recently, it has been found to cross intact cellular membranes and the skin very readily and to effect rapid penetration through these tissues of some substances dissolved in it 2,3 . Despite these remarkable abilities, very few undesirable effects in either experimental animals 4 or in man have been reported. As a result, DMSO is coming into rather widespread use as therapy for a number of human diseases 5 .
ISSN:0028-0836
1476-4687
DOI:10.1038/212405a0