Hormone-Enzyme Complex: Insulin-Hexokinase

CORTISONE acetate dissolved in β-lipoprotein (isolated from blood plasma of normal animals) has been shown to inhibit the activity of yeast hexokinase, while on addition of insulin the inhibition is reversed, and the activity of the enzyme restored 1 . It has also been found that blocking of yeast h...

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Bibliographic Details
Published in:Nature (London) 1966-08, Vol.211 (5049), p.644-645
Main Authors: ILYIN, V. S, TITOVA, G. V
Format: Article
Language:English
Subjects:
Densitometry
Electrophoresis
Enzymes
Hexokinase - analysis
Humanities and Social Sciences
Insulin - analysis
letter
multidisciplinary
Science
Science (multidisciplinary)
Sulfhydryl Compounds - pharmacology
Yeasts - enzymology
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Summary:CORTISONE acetate dissolved in β-lipoprotein (isolated from blood plasma of normal animals) has been shown to inhibit the activity of yeast hexokinase, while on addition of insulin the inhibition is reversed, and the activity of the enzyme restored 1 . It has also been found that blocking of yeast hexokinase sulphydryl groups with parachlormercuribenzoate 2 or N -ethylmaleimide 3 failed to affect the activity of the enzyme. Consequently, it was obvious that sulphydryl groups of hexokinase played no part in catalysis of the glucokinase reaction 4 .
ISSN:0028-0836
1476-4687
DOI:10.1038/211644a0