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Effect of Alginate on the Absorption of Lead in Man
EXPERIMENTS carried out in this laboratory have shown that adding an alginate derivative rich in guluronic acid to the diet of man, in the proportion of 10 g of alginate to 1 g of dietary calcium, reduces the absorption of strontium, and therefore strontium-90, by a factor of four 1 . Indeed, for a...
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| Published in: | Nature (London) 1969-12, Vol.224 (5224), p.1115-1116 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c366t-41a8e0fa0a981036d6fa96bafa15838a0057ee9620a02a4e4a76ce7c1e57a12a3 |
| container_end_page | 1116 |
| container_issue | 5224 |
| container_start_page | 1115 |
| container_title | Nature (London) |
| container_volume | 224 |
| creator | HARRISON, G. E CARR, T. E. F SUTTON, ALICE HUMPHREYS, E. R RUNDO, J |
| description | EXPERIMENTS carried out in this laboratory have shown that adding an alginate derivative rich in guluronic acid to the diet of man, in the proportion of 10 g of alginate to 1 g of dietary calcium, reduces the absorption of strontium, and therefore strontium-90, by a factor of four
1
. Indeed, for a milk diet, the corresponding decrease was about six-fold
2
, and, in these conditions, the absorption of calcium was decreased only by a few per cent. Ideally, an alginate supplement should suppress the absorption of strontium without affecting the absorption of essential elements, and it has been shown that there was no reduction in the absorption of Na, K, Ca, Mg, Fe or Zn or in the body retention of P (ref. 3) in rats fed for a year on a commercial diet containing 10 per cent of commercial alginate (Manucol SS/LD/2, Alginate Industries, Ltd). |
| doi_str_mv | 10.1038/2241115b0 |
| format | article |
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1
. Indeed, for a milk diet, the corresponding decrease was about six-fold
2
, and, in these conditions, the absorption of calcium was decreased only by a few per cent. Ideally, an alginate supplement should suppress the absorption of strontium without affecting the absorption of essential elements, and it has been shown that there was no reduction in the absorption of Na, K, Ca, Mg, Fe or Zn or in the body retention of P (ref. 3) in rats fed for a year on a commercial diet containing 10 per cent of commercial alginate (Manucol SS/LD/2, Alginate Industries, Ltd).</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/2241115b0</identifier><identifier>PMID: 5353725</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Alginates - pharmacology ; Diet ; Feces - analysis ; Humanities and Social Sciences ; Humans ; Intestinal Absorption - drug effects ; Lead - metabolism ; Lead - urine ; letter ; multidisciplinary ; Radioisotopes ; Science ; Science (multidisciplinary)</subject><ispartof>Nature (London), 1969-12, Vol.224 (5224), p.1115-1116</ispartof><rights>Springer Nature Limited 1969</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-41a8e0fa0a981036d6fa96bafa15838a0057ee9620a02a4e4a76ce7c1e57a12a3</citedby><cites>FETCH-LOGICAL-c366t-41a8e0fa0a981036d6fa96bafa15838a0057ee9620a02a4e4a76ce7c1e57a12a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5353725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HARRISON, G. E</creatorcontrib><creatorcontrib>CARR, T. E. F</creatorcontrib><creatorcontrib>SUTTON, ALICE</creatorcontrib><creatorcontrib>HUMPHREYS, E. R</creatorcontrib><creatorcontrib>RUNDO, J</creatorcontrib><title>Effect of Alginate on the Absorption of Lead in Man</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>EXPERIMENTS carried out in this laboratory have shown that adding an alginate derivative rich in guluronic acid to the diet of man, in the proportion of 10 g of alginate to 1 g of dietary calcium, reduces the absorption of strontium, and therefore strontium-90, by a factor of four
1
. Indeed, for a milk diet, the corresponding decrease was about six-fold
2
, and, in these conditions, the absorption of calcium was decreased only by a few per cent. Ideally, an alginate supplement should suppress the absorption of strontium without affecting the absorption of essential elements, and it has been shown that there was no reduction in the absorption of Na, K, Ca, Mg, Fe or Zn or in the body retention of P (ref. 3) in rats fed for a year on a commercial diet containing 10 per cent of commercial alginate (Manucol SS/LD/2, Alginate Industries, Ltd).</description><subject>Alginates - pharmacology</subject><subject>Diet</subject><subject>Feces - analysis</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Intestinal Absorption - drug effects</subject><subject>Lead - metabolism</subject><subject>Lead - urine</subject><subject>letter</subject><subject>multidisciplinary</subject><subject>Radioisotopes</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><recordid>eNptkD1PwzAQhi0EKqUw8AMQnpBACtixYztjVJUPqYgF5uiSnkuqNC52MvDvMUpVFqbT6X306u4h5JKze86EeUhTyTnPKnZEplxqlUhl9DGZMpaahBmhTslZCBvGWMa1nJBJJjKh02xKxMJarHvqLC3addNBj9R1tP9EWlTB-V3fxDWmS4QVbTr6Ct05ObHQBrzYzxn5eFy8z5-T5dvTy7xYJrVQqk8kB4PMAoPcxCvVSlnIVQUWeGaEgXiMRsxVyoClIFGCVjXqmmOmgacgZuRm7N159zVg6MttE2psW-jQDaE0UnCd5zqCtyNYexeCR1vufLMF_11yVv4KKg-CInu1Lx2qLa4O5N5IzO_GPMSkW6MvN27wXfzz37LrEY7eBo-Hsj_iB7K3dRg</recordid><startdate>19691213</startdate><enddate>19691213</enddate><creator>HARRISON, G. E</creator><creator>CARR, T. E. F</creator><creator>SUTTON, ALICE</creator><creator>HUMPHREYS, E. R</creator><creator>RUNDO, J</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19691213</creationdate><title>Effect of Alginate on the Absorption of Lead in Man</title><author>HARRISON, G. E ; CARR, T. E. F ; SUTTON, ALICE ; HUMPHREYS, E. R ; RUNDO, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-41a8e0fa0a981036d6fa96bafa15838a0057ee9620a02a4e4a76ce7c1e57a12a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Alginates - pharmacology</topic><topic>Diet</topic><topic>Feces - analysis</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Intestinal Absorption - drug effects</topic><topic>Lead - metabolism</topic><topic>Lead - urine</topic><topic>letter</topic><topic>multidisciplinary</topic><topic>Radioisotopes</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HARRISON, G. E</creatorcontrib><creatorcontrib>CARR, T. E. F</creatorcontrib><creatorcontrib>SUTTON, ALICE</creatorcontrib><creatorcontrib>HUMPHREYS, E. R</creatorcontrib><creatorcontrib>RUNDO, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HARRISON, G. E</au><au>CARR, T. E. F</au><au>SUTTON, ALICE</au><au>HUMPHREYS, E. R</au><au>RUNDO, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Alginate on the Absorption of Lead in Man</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1969-12-13</date><risdate>1969</risdate><volume>224</volume><issue>5224</issue><spage>1115</spage><epage>1116</epage><pages>1115-1116</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>EXPERIMENTS carried out in this laboratory have shown that adding an alginate derivative rich in guluronic acid to the diet of man, in the proportion of 10 g of alginate to 1 g of dietary calcium, reduces the absorption of strontium, and therefore strontium-90, by a factor of four
1
. Indeed, for a milk diet, the corresponding decrease was about six-fold
2
, and, in these conditions, the absorption of calcium was decreased only by a few per cent. Ideally, an alginate supplement should suppress the absorption of strontium without affecting the absorption of essential elements, and it has been shown that there was no reduction in the absorption of Na, K, Ca, Mg, Fe or Zn or in the body retention of P (ref. 3) in rats fed for a year on a commercial diet containing 10 per cent of commercial alginate (Manucol SS/LD/2, Alginate Industries, Ltd).</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>5353725</pmid><doi>10.1038/2241115b0</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1969-12, Vol.224 (5224), p.1115-1116 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84317997 |
| source | Nature |
| subjects | Alginates - pharmacology Diet Feces - analysis Humanities and Social Sciences Humans Intestinal Absorption - drug effects Lead - metabolism Lead - urine letter multidisciplinary Radioisotopes Science Science (multidisciplinary) |
| title | Effect of Alginate on the Absorption of Lead in Man |
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