Effect of Thorazine (Chlorpromazine) on Collagen Metabolism

IN the course of an investigation of the effect of partial body X-irradiation on collagen metabolism we used thorazine (chlorpromazine) as an aid in immobilizing rats 1 . We found quite unexpectedly that the incorporation of carbon-14-labelled amino-acids into collagen was markedly suppressed during...

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Bibliographic Details
Published in:Nature (London) 1966-08, Vol.211 (5051), p.880-881
Main Authors: ERNST, H, TRAELNES, K. R, ALTMAN, K. I, HEMPELMANN, L. H
Format: Article
Language:English
Subjects:
Animals
Carbon Isotopes
Chlorpromazine - pharmacology
Collagen - biosynthesis
DNA - analysis
Glycine - metabolism
Granuloma - metabolism
Humanities and Social Sciences
In Vitro Techniques
letter
multidisciplinary
Rats
Science
Science (multidisciplinary)
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Summary:IN the course of an investigation of the effect of partial body X-irradiation on collagen metabolism we used thorazine (chlorpromazine) as an aid in immobilizing rats 1 . We found quite unexpectedly that the incorporation of carbon-14-labelled amino-acids into collagen was markedly suppressed during the first month, and considerably enhanced 2–4 months after the injection of the drugs. The effect of thorazine on collagen metabolism was observed in all tissues, but was most pronounced in bone collagen. Because of the involvement of bone collagen, we feel that our findings should be brought to the attention of clinicians who may be treating fracture cases with, among other drugs, thorazine, a drug which may impair the healing process.
ISSN:0028-0836
1476-4687
DOI:10.1038/211880a0