Alkaloids of Acronychia Baueri Schott I: Isolation of the Alkaloids and a Study of the Antitumor and Other Biological Properties of Acronycine

Utilizing a differential extraction technique for the examination of the bark of the Australian plant Acronychia Baueri Schott (Bauerella australiana Borzi), has resulted in the isolation of the triterpene lupeol and the alkaloids melicopine, acronycine, and normelicopidine. The experimental antitum...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1966-08, Vol.55 (8), p.758-768
Main Authors: Svoboda, Gordon H., Poore, Gerald A., Simpson, Patrick J., Boder, George B.
Format: Article
Language:English
Subjects:
Alkaloids - administration & dosage
Alkaloids - pharmacology
Alkaloids - therapeutic use
Animals
Anthracenes - pharmacology
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Blood Protein Electrophoresis
Carcinoma, Ehrlich Tumor - drug therapy
Carcinoma, Squamous Cell - drug therapy
Cell Division - drug effects
Cerebrovascular Disorders
Cricetinae
Culture Techniques
Eukaryota - drug effects
Female
Leukemia, Experimental - drug therapy
Mice
Neoplasms, Experimental - drug therapy
Plants, Medicinal
Rats
Sarcoma 180 - drug therapy
Sarcoma, Experimental - drug therapy
Vinblastine - pharmacology
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Summary:Utilizing a differential extraction technique for the examination of the bark of the Australian plant Acronychia Baueri Schott (Bauerella australiana Borzi), has resulted in the isolation of the triterpene lupeol and the alkaloids melicopine, acronycine, and normelicopidine. The experimental antitumor activity associated with the crude alkaloidal mixture obtained from the ether extract has been shown to be attributable to acronycine. Experimental evidence is herein given, showing acronycine to have the broadest antitumor spectrum of any alkaloid isolated to date in these laboratories. By virtue of its being chemically unrelated to any of the presently utilized antitumor agents it represents a new lead in the search for agents effective in the chemotherapeutic management of human neoplasms.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600550803