Characterization of protein therapeutics by mass spectrometry: recent developments and future directions

Mass spectrometry (MS) has become a powerful technology in the discovery and development of protein therapeutics in the biopharmaceutical industry. This review article describes recent developments and future trends in the characterization of protein therapeutics using MS. We discuss top-down MS for...

Full description

Saved in:
Bibliographic Details
Published in:Drug discovery today 2011, Vol.16 (1), p.58-64
Main Authors: Chen, Guodong, Warrack, Bethanne M., Goodenough, Angela K., Wei, Hui, Wang-Iverson, David B., Tymiak, Adrienne A.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Drug Discovery - methods
Drug Discovery - trends
Forecasting
General pharmacology
Humans
Mass Spectrometry - methods
Mass Spectrometry - trends
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Proteins - chemistry
Proteins - pharmacokinetics
Proteins - therapeutic use
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mass spectrometry (MS) has become a powerful technology in the discovery and development of protein therapeutics in the biopharmaceutical industry. This review article describes recent developments and future trends in the characterization of protein therapeutics using MS. We discuss top-down MS for the characterization of protein modifications, hydrogen/deuterium exchange MS and ion mobility MS methods for higher order protein structure studies. Quantitative analysis of protein therapeutics ( in vivo) by MS as an orthogonal approach to immunoassay for pharmacokinetics studies will also be illustrated.
ISSN:1359-6446
1878-5832
DOI:10.1016/j.drudis.2010.11.003