Phospholipid Composition of Erythrocytes and Glutathione Redox System in Rats during Adaptation to Cholesterol Load

We studied phospholipid composition of erythrocytes and the state of the glutathione redox system in rats during adaptation to cholesterol load for 180 days. The adaptive response is formed during the period from day 30 to day 90 of cholesterol load and is associated with increased relative content...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2011, Vol.150 (3), p.291-294
Main Authors: Karaman, Yu. K., Novgorodtseva, T. P., Zhukova, N. V.
Format: Article
Language:English
Subjects:
Adaptation, Physiological - physiology
Animals
Biomedical and Life Sciences
Biomedicine
Blood Chemical Analysis
Cell Biology
Cholesterol - blood
Diabetes
Erythrocytes - chemistry
General Pathology and Pathophysiology
Glutathione - biosynthesis
Glutathione Peroxidase - metabolism
Glutathione Reductase - metabolism
Internal Medicine
Laboratory Medicine
Lipids
Male
Oxidation-Reduction
Pathology
Phospholipids - analysis
Rats
Rats, Wistar
Resveratrol
Statistics, Nonparametric
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Summary:We studied phospholipid composition of erythrocytes and the state of the glutathione redox system in rats during adaptation to cholesterol load for 180 days. The adaptive response is formed during the period from day 30 to day 90 of cholesterol load and is associated with increased relative content of phosphatidylethanolamine and phosphatidylinositol, activation of glutathione redox system enzymes (glutathione reductase and glutathione peroxidase), and enhanced production of glutathione.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-011-1125-2